Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin

Evidence for regulation of circulating leptin by insulin is conflicting. Diabetes was induced in rats with streptozotocin (STZ; 40 mg ⋅ kg ⋅ day × 2 days) to examine the effect of insulin-deficient diabetes and insulin treatment on circulating leptin. After 12 wk, plasma leptin concentrations in unt...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-05, Vol.274 (5), p.R1482
Main Authors: Havel, Peter J, Uriu-Hare, Janet Y, Liu, Tina, Stanhope, Kimber L, Stern, Judith S, Keen, Carl L, Ahrén, Bo
Format: Article
Language:English
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Summary:Evidence for regulation of circulating leptin by insulin is conflicting. Diabetes was induced in rats with streptozotocin (STZ; 40 mg ⋅ kg ⋅ day × 2 days) to examine the effect of insulin-deficient diabetes and insulin treatment on circulating leptin. After 12 wk, plasma leptin concentrations in untreated rats were all
ISSN:1522-1490