Fibroblast growth factor-23 is a strong predictor of insulin resistance among chronic kidney disease patients

Insulin resistance (IR) is very common among chronic kidney disease (CKD) patients. Disturbance in mineral and bone metabolism (MBD) seems to play a role in the pathogenesis of insulin resistance. Fibroblast growth factor-23 (FGF23) is evolving as the most important link between MBD and many patholo...

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Bibliographic Details
Published in:Renal failure 2018-11, Vol.40 (1), p.226-230
Main Authors: Fayed, Ahmed, El Nokeety, Mahmoud M., Heikal, Ahmed A., Abdulazim, Dina O., Naguib, Mervat M., Sharaf El Din, Usama A. A.
Format: Article
Language:English
Subjects:
25 OH vitamin D
Adult
Blood Glucose
Body Mass Index
Bone growth
Bone turnover
Calcium - blood
Calcium - metabolism
Case-Control Studies
CKD-MBD
Clinical Study
Creatinine - urine
Dialysis
Disease resistance
Fasting
Female
FGF23
Fibroblast growth factor 23
Fibroblast Growth Factors - blood
Fibroblasts
Glomerular Filtration Rate
Growth factors
HOMA-IR
Humans
Insulin Resistance
Kidney diseases
Male
Metabolism
Parathyroid hormone
Phosphates - blood
Phosphates - metabolism
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - metabolism
Renal Insufficiency, Chronic - urine
Uric acid
Uric Acid - blood
Vitamin D
Young Adult
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Summary:Insulin resistance (IR) is very common among chronic kidney disease (CKD) patients. Disturbance in mineral and bone metabolism (MBD) seems to play a role in the pathogenesis of insulin resistance. Fibroblast growth factor-23 (FGF23) is evolving as the most important link between MBD and many pathologic sequences of CKD. The aim was to evaluate IR in pre-dialysis CKD patients looking for a possible association to mineral metabolism among CKD patients. A total of 100 stage 3-5 CKD patients were selected beside 20 normal control subjects. Homeostatic model assessment of insulin resistance (HOMA-IR) was used to assess IR in selected cases. Both groups were compared for fasting blood glucose (FBG), fasting blood insulin (FBI), HOMA-IR, estimated glomerular filtration rate (eGFR), serum calcium (Ca), phosphorus (P), 25 hydroxy vitamin D (25 OH vit D), parathormone (PTH), and uric acid (UA). Correlation study between HOMA_IR and different studied parameters was performed. HOMA-IR is significantly higher in CKD (8.87 ± 3.48 vs. 3.97 ± 0.34 in CKD vs. control, respectively, p 
ISSN:0886-022X
1525-6049
DOI:10.1080/0886022X.2018.1455594