Electrochemical dehydrogenative cyclization of 1,3-dicarbonyl compounds

The intramolecular C(sp 3 )-H/C(sp 2 )-H cross-coupling of 1,3-dicarbonyl compounds has been achieved through Cp 2 Fe-catalyzed electrochemical oxidation. The key to the success of these dehydrogenative cyclization reactions is the selective activation of the acidic α-C-H bond of the 1,3-dicarbonyl...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (36), p.461-464
Main Authors: Wu, Zheng-Jian, Li, Shi-Rui, Long, Hao, Xu, Hai-Chao
Format: Article
Language:English
Subjects:
Chemical reactions
Coupling (molecular)
Cross coupling
Dehydrogenation
Electrochemical oxidation
Hydrogen bonds
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Summary:The intramolecular C(sp 3 )-H/C(sp 2 )-H cross-coupling of 1,3-dicarbonyl compounds has been achieved through Cp 2 Fe-catalyzed electrochemical oxidation. The key to the success of these dehydrogenative cyclization reactions is the selective activation of the acidic α-C-H bond of the 1,3-dicarbonyl moiety to generate a carbon-centered radical. The intramolecular C(sp 3 )-H/C(sp 2 )-H cross-coupling of 1,3-dicarbonyl compounds has been achieved through Cp 2 Fe-catalyzed electrochemical oxidation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc02472c