Adenylate Cyclase Type 9 (ADCY9) Inactivation Protects from Atherosclerosis Only in the Absence of Cholesteryl Ester Transfer Protein (CETP)

-Pharmacogenomic studies have shown that genotype determines the effects of the cholesteryl ester transfer protein (CETP) inhibitor dalcetrapib on cardiovascular events and atherosclerosis imaging. The underlying mechanisms responsible for the interactions between and CETP activity have not yet been...

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Published in:Circulation (New York, N.Y.) N.Y.), 2018-04
Main Authors: Rautureau, Yohann, Deschambault, Vanessa, Higgins, Marie-Ève, Rivas, Daniel, Mecteau, Mélanie, Geoffroy, Pascale, Miquel, Géraldine, Uy, Kurunradeth, Sanchez, Rocio, Lavoie, Véronique, Brand, Geneviève, Nault, Audrey, Williams, Pierre-Marc, Suarez, Maria Laura, Merlet, Nolwenn, Lapointe, Line, Duquette, Natacha, Gillis, Marc-Antoine, Samami, Samaneh, Mayer, Gaétan, Pouliot, Philippe, Raignault, Adeline, Maafi, Foued, Brodeur, Mathieu R, Levesque, Sylvie, Guertin, Marie-Claude, Dubé, Marie-Pierre, Thorin, Éric, Rhainds, David, Rhéaume, Éric, Tardif, Jean-Claude
Format: Article
Language:English
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Summary:-Pharmacogenomic studies have shown that genotype determines the effects of the cholesteryl ester transfer protein (CETP) inhibitor dalcetrapib on cardiovascular events and atherosclerosis imaging. The underlying mechanisms responsible for the interactions between and CETP activity have not yet been determined. - -inactivated ( ) and wild-type (WT) mice, that were or not transgenic for the gene (CETPtg and CETPtg ), were submitted to an atherogenic protocol (injection of an AAV8 expressing a PCSK9 gain-of-function variant and 0.75% cholesterol diet for 16 weeks). Atherosclerosis, vasorelaxation, telemetry and adipose tissue MRI were evaluated. - mice had a 65% reduction in aortic atherosclerosis compared to WT (
ISSN:1524-4539
DOI:10.1161/CIRCULATIONAHA.117.031134