Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobu...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-05, Vol.54 (43), p.5422-5425
Main Authors: Cantarutti, Cristina, Raj, Gijo, Fogolari, Federico, Giorgetti, Sofia, Corazza, Alessandra, Bellotti, Vittorio, Naumov, Pan e, Esposito, Gennaro
Format: Article
Language:English
Subjects:
Fibrillation
Gold
Nanoparticles
NMR
Nuclear magnetic resonance
Oligomers
Proteins
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Summary:Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers. Citrate-coated gold nanoparticles interfere with the association equilibria of β2-microglobulin and thus inhibit the early events of fibrillogenesis.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc01053f