ANALYSIS OF γ-GLUTAMYL CARBOXYLASE GENE rs2592551 POLYMORPHISM ASSOCIATION WITH ISCHEMIC ATHEROTHROMBOTIC STROKE

The results of γ-glutamyl carboxylase gene rs2592551 polymorphism determining in 170 patients with ischemic atherothrombotic stroke and 124 subjects without acute cerebrovascular disease (control group) have been evaluated. Obtained results revealed that rs2592551 polymorphism was related to ischemi...

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Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2017, Vol.63 (1), p.33
Main Authors: Dubovyk, Ye I, Harbuzova, V Yu, Obukhova, O A, Ataman, A V
Format: Article
Language:Ukrainian
Subjects:
Adult
Aged
Aged, 80 and over
Alleles
Atherosclerosis - enzymology
Atherosclerosis - genetics
Atherosclerosis - pathology
Body Mass Index
Brain Ischemia - enzymology
Brain Ischemia - genetics
Brain Ischemia - pathology
Carbon-Carbon Ligases - genetics
Carbon-Carbon Ligases - metabolism
Case-Control Studies
Female
Gene Expression
Gene Frequency
Genetic Predisposition to Disease
Heterozygote
Humans
Hypertension - physiopathology
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors
Sex Factors
Smoking - physiopathology
Stroke - enzymology
Stroke - genetics
Stroke - pathology
Ukraine
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Summary:The results of γ-glutamyl carboxylase gene rs2592551 polymorphism determining in 170 patients with ischemic atherothrombotic stroke and 124 subjects without acute cerebrovascular disease (control group) have been evaluated. Obtained results revealed that rs2592551 polymorphism was related to ischemic stroke in Ukrainian population. The risk for this disease in patients with T/T genotype was higher than in major C-allele carriers (odds ratio (OR) = 3.117; 95% confidence interval (CI) = 1.016-9.566; P = 0.047). After dividing patients into subgroups, formed by the presence of certain risk factors for atherosclerosis, similar association has been established for women and non-smokers. At the same time, the heterozygous genotype (C/T) in females had significantly protective effect against ischemic stroke development when compared to C/C and T/T genotypes (OR = 0.460; 95% CI 0.213-0.994; P = 0.048). Statistical significance of these results persisted even after adjustment for age, body mass index, smoking and hypertension.
ISSN:2522-9028