Aspirin, platelet inhibition and cancer prevention

Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharma...

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Bibliographic Details
Published in:Platelets (Edinburgh) 2018-11, Vol.29 (8), p.779-785
Main Authors: Patrignani, Paola, Patrono, Carlo
Format: Article
Language:English
Subjects:
Aspirin
colorectal cancer
cyclooxygenases
platelet activation
prostaglandin E2
thromboxane A2
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Summary:Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose aspirin as a basis for discussing the mechanisms underlying the contribution of platelets to neoplastic transformation and progression of cancer via the development of metastases.
ISSN:0953-7104
1369-1635
DOI:10.1080/09537104.2018.1492105