Dietary polyphenols and type 2 diabetes: Human Study and Clinical Trial

Significant evidence from epidemiological investigations showed that dietary polyphenols might manage and prevent type 2 diabetes (T2D). This review summarizes human studies and clinical trials of polyphenols as anti-diabetic agents. Polyphenols from coffee, guava tea, whortleberry, olive oil, propo...

Full description

Saved in:
Bibliographic Details
Published in:Critical reviews in food science and nutrition 2019-11, Vol.59 (20), p.3371-3379
Main Authors: Cao, Hui, Ou, Juanying, Chen, Lei, Zhang, Yanbo, Szkudelski, Tomasz, Delmas, Dominique, Daglia, Maria, Xiao, Jianbo
Format: Article
Language:English
Subjects:
Anthocyanins
Blood Glucose
Chocolate
clinical trial
Clinical trials
Clinical Trials as Topic
Cocoa
Coffee
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - therapy
Diet
Dietary polyphenols
Epidemiology
Flavonoids
Glucose
Glucose metabolism
Guava
human Study
Humans
Hypoglycemic Agents - pharmacology
Insulin
Insulin Resistance
Insulin secretion
Oils & fats
Olive oil
Polyphenols
Polyphenols - pharmacology
Propolis
Resveratrol
Secretion
Secretions
Tea
type 2 diabetes
Wine
Wines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Significant evidence from epidemiological investigations showed that dietary polyphenols might manage and prevent type 2 diabetes (T2D). This review summarizes human studies and clinical trials of polyphenols as anti-diabetic agents. Polyphenols from coffee, guava tea, whortleberry, olive oil, propolis, chocolate, red wine, grape seed, and cocoa have been reported to show anti-diabetic effects in T2D patients through increasing glucose metabolism, improving vascular function as well as reducing insulin resistance and HbA1c level. However, individual flavonoid or isoflavonoid compounds appear to have no therapeutic effect on diabetes, based on the limited clinical data. Preliminary clinical trials provided evidence that resveratrol had anti-diabetic activity in humans by improving glycemic control in subjects with insulin resistance. Besides, anthocyanins exhibited anti-diabetic properties by reducing blood glucose and HbA1c levels or the improvement of insulin secretion and resistance. The structure-activity relationship of polyphenols as anti-diabetic agents in humans has been rarely reported.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2018.1492900