DNA logic assembly powered by a triplex-helix molecular switch for extracellular pH imaging

We demonstrate a strategy for pH-programmable self-assembly of DNA nanostructures by taking advantage of the pH dependence of reverse Hoogsteen interactions for a triplex-helix molecular switch. This strategy is successfully applied to the construction of molecular logic gates and imaging of extrace...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-07, Vol.54 (61), p.8498-851
Main Authors: Qi, Hongjie, Yue, Shuzhen, Bi, Sai, Ding, Caifeng, Song, Weiling
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
Dependence
DNA
Logic circuits
Molecular chains
Molecular machines
Self-assembly
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Summary:We demonstrate a strategy for pH-programmable self-assembly of DNA nanostructures by taking advantage of the pH dependence of reverse Hoogsteen interactions for a triplex-helix molecular switch. This strategy is successfully applied to the construction of molecular logic gates and imaging of extracellular pH. A strategy is rationally designed to finely control the hybridization chain reaction (HCR) for the self-assembly of DNA nanostructures by simply changing the pH, which is successfully applied to molecular logic operations and extracellular pH imaging.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc04615h