Investigation and Comparison of In Vitro Genotoxic Potency of PM 10 Collected in Rural and Urban Sites at Tehran in Different Metrological Conditions and Different Seasons

The particulate matter has become a serious health problem in some large cities in the world. These particles are a complex mixture of chemical compounds which change based on location and time and, consequently, can cause different health-related effects. The exact mechanism of the effect of these...

Full description

Saved in:
Bibliographic Details
Published in:Biological trace element research 2019-05, Vol.189 (1), p.301
Main Authors: Ghanbarian, Maryam, Nicknam, Mohammad Hossein, Mesdaghinia, Alireza, Yunesian, Masud, Hassanvand, Mohammad Sadegh, Soleimanifar, Narjes, Rezaei, Soheila, Atafar, Zahra, Ghanbarian, Marjan, Faraji, Maryam, Ghozikali, Mohammad Ghanbari, Naddafi, Kazem
Format: Article
Language:English
Subjects:
A549 Cells
DNA Damage - drug effects
DNA Damage - genetics
Environmental Monitoring
Humans
Particulate Matter - toxicity
Seasons
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The particulate matter has become a serious health problem in some large cities in the world. These particles are a complex mixture of chemical compounds which change based on location and time and, consequently, can cause different health-related effects. The exact mechanism of the effect of these particles is not yet known for certain. However, it seems that numerous mechanisms through the production of ROS and, eventually, DNA destruction, which are related to a wide range of diseases, are among the causes of particles' health-related effects. The present study is aimed to evaluate and compare the genotoxicity potential of particles collected in Tehran, Iran, in urban and rural regions during spring and autumn as well as dusty and inversion conditions. These effects were examined using the comet assay on human pulmonary epithelial cells (A549). Results showed that all the particles had the potential for genotoxicity at the concentration used in this study (75,150 and 300 μg/ml). Moreover, DNA destruction changed with season, site, and even dusty and inversion atmospheric conditions. These changes mostly belonged to urban particles. In general, urban particles in autumn and, specifically, on days with inversion had higher genotoxicity (p 
ISSN:1559-0720