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Deoxyadenosine metabolism and toxicity in cultured L5178Y cells

The growth of cultured L5178Y cells is inhibited by relatively low concentrations fo deoxyadenosine in the presence of deoxycoformycin, an inhibitor of adenosine deaminase. Cell viability is reduced, presumably as a consequence of the induced state of unbalanced growth which is characterized by inhi...

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Published in:	Cancer research (Chicago, Ill.) Ill.), 1977-09, Vol.37 (9), p.3013
Main Authors:	Lowe, J K, Gowans, B, Brox, L
Format:	Article
Language:	English
Subjects:	Adenosine Deaminase Inhibitors Animals Azepines - pharmacology Cell Division - drug effects Cell Survival - drug effects Cells, Cultured Deoxyadenosines - metabolism Deoxyadenosines - pharmacology Deoxyribonucleotides - metabolism Deoxyribonucleotides - pharmacology Leukemia, Experimental - drug therapy Leukemia, Experimental - metabolism Leukemia, Experimental - pathology
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container_title	Cancer research (Chicago, Ill.)
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creator	Lowe, J K Gowans, B Brox, L
description	The growth of cultured L5178Y cells is inhibited by relatively low concentrations fo deoxyadenosine in the presence of deoxycoformycin, an inhibitor of adenosine deaminase. Cell viability is reduced, presumably as a consequence of the induced state of unbalanced growth which is characterized by inhibition in DNA synthesis, accumulation of cells in G1 or early S phase, a continuation in RNA synthesis, and increasing cell volume. The intracellular concentrations of purine and pyrimidine ribonucleoside phosphates remain essentially unchanged. The significant changes in the intracellular deoxynucleoside triphosphate pools are an increase in deoxyadenosine triphosphate and a decrease in deoxycytidine triphosphate.
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Cell viability is reduced, presumably as a consequence of the induced state of unbalanced growth which is characterized by inhibition in DNA synthesis, accumulation of cells in G1 or early S phase, a continuation in RNA synthesis, and increasing cell volume. The intracellular concentrations of purine and pyrimidine ribonucleoside phosphates remain essentially unchanged. 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Cell viability is reduced, presumably as a consequence of the induced state of unbalanced growth which is characterized by inhibition in DNA synthesis, accumulation of cells in G1 or early S phase, a continuation in RNA synthesis, and increasing cell volume. The intracellular concentrations of purine and pyrimidine ribonucleoside phosphates remain essentially unchanged. The significant changes in the intracellular deoxynucleoside triphosphate pools are an increase in deoxyadenosine triphosphate and a decrease in deoxycytidine triphosphate.</description><subject>Adenosine Deaminase Inhibitors</subject><subject>Animals</subject><subject>Azepines - pharmacology</subject><subject>Cell Division - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Deoxyadenosines - metabolism</subject><subject>Deoxyadenosines - pharmacology</subject><subject>Deoxyribonucleotides - metabolism</subject><subject>Deoxyribonucleotides - pharmacology</subject><subject>Leukemia, Experimental - drug therapy</subject><subject>Leukemia, Experimental - metabolism</subject><subject>Leukemia, Experimental - pathology</subject><issn>0008-5472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><recordid>eNotj8lqwzAUAHXolqb9gx70AwYt1pJTKemSgqGX9tBTeJKeqIpsB0uG-O8bSE_DXAbmgqwYY7ZRrRE35LaU35MqztQ1uZKMGyNW5PEZx-MCAYexpAFpjxXcmFPpKQyB1vGYfKoLTQP1c67zhIF2ihv7TT3mXO7IZYRc8P6fa_L1-vK53TXdx9v79qlrfoS0tYnGOaaYadGiNhvwwXoedfTgFIeWn8THoCAKjtYE7bQQG9kyJkHKoKNck4dz9zC7HsP-MKUepmV__pB_NyxDMw</recordid><startdate>197709</startdate><enddate>197709</enddate><creator>Lowe, J K</creator><creator>Gowans, B</creator><creator>Brox, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197709</creationdate><title>Deoxyadenosine metabolism and toxicity in cultured L5178Y cells</title><author>Lowe, J K ; Gowans, B ; Brox, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-f7bb05074e8e679acd8c1f6fcab51a41c1fcfd5af21e87d6b622934003a33d6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adenosine Deaminase Inhibitors</topic><topic>Animals</topic><topic>Azepines - pharmacology</topic><topic>Cell Division - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>Deoxyadenosines - metabolism</topic><topic>Deoxyadenosines - pharmacology</topic><topic>Deoxyribonucleotides - metabolism</topic><topic>Deoxyribonucleotides - pharmacology</topic><topic>Leukemia, Experimental - drug therapy</topic><topic>Leukemia, Experimental - metabolism</topic><topic>Leukemia, Experimental - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lowe, J K</creatorcontrib><creatorcontrib>Gowans, B</creatorcontrib><creatorcontrib>Brox, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lowe, J K</au><au>Gowans, B</au><au>Brox, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deoxyadenosine metabolism and toxicity in cultured L5178Y cells</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1977-09</date><risdate>1977</risdate><volume>37</volume><issue>9</issue><spage>3013</spage><pages>3013-</pages><issn>0008-5472</issn><abstract>The growth of cultured L5178Y cells is inhibited by relatively low concentrations fo deoxyadenosine in the presence of deoxycoformycin, an inhibitor of adenosine deaminase. Cell viability is reduced, presumably as a consequence of the induced state of unbalanced growth which is characterized by inhibition in DNA synthesis, accumulation of cells in G1 or early S phase, a continuation in RNA synthesis, and increasing cell volume. The intracellular concentrations of purine and pyrimidine ribonucleoside phosphates remain essentially unchanged. The significant changes in the intracellular deoxynucleoside triphosphate pools are an increase in deoxyadenosine triphosphate and a decrease in deoxycytidine triphosphate.</abstract><cop>United States</cop><pmid>301772</pmid></addata></record>
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language	eng
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source	EZB-FREE-00999 freely available EZB journals
subjects	Adenosine Deaminase Inhibitors Animals Azepines - pharmacology Cell Division - drug effects Cell Survival - drug effects Cells, Cultured Deoxyadenosines - metabolism Deoxyadenosines - pharmacology Deoxyribonucleotides - metabolism Deoxyribonucleotides - pharmacology Leukemia, Experimental - drug therapy Leukemia, Experimental - metabolism Leukemia, Experimental - pathology
title	Deoxyadenosine metabolism and toxicity in cultured L5178Y cells
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