A green chemical oligomerization of phloroglucinol induced by plasma as novel α-glucosidase inhibitors

A new facile method was developed for simple green synthesis of methylene-bridged phloroglucinol oligomers using nonthermal dielectric barrier discharge (DBD) plasma in methanolic solution. The chemical structures of these newly generated oligomers 2-5 were determined by interpretation of the spectr...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2018-12, Vol.82 (12), p.2059-2063
Main Authors: Choi, Soon Ho, Jeong, Gyeong Han, Lee, Kyung-Bon, Jo, Cheorun, Kim, Tae Hoon
Format: Article
Language:English
Subjects:
anti-diabetes
Carbon-13 Magnetic Resonance Spectroscopy
Chromatography, High Pressure Liquid
Diabetes Mellitus, Type 2 - drug therapy
dielectric barrier discharge plasma
Glycoside Hydrolase Inhibitors - chemistry
Glycoside Hydrolase Inhibitors - pharmacology
Glycoside Hydrolase Inhibitors - therapeutic use
Green Chemistry Technology
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Molecular Structure
oligomerization
Phloroglucinol
Phloroglucinol - chemistry
Plasma Gases
Polymerization
Proton Magnetic Resonance Spectroscopy
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Ultraviolet
α-glucosidase
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Summary:A new facile method was developed for simple green synthesis of methylene-bridged phloroglucinol oligomers using nonthermal dielectric barrier discharge (DBD) plasma in methanolic solution. The chemical structures of these newly generated oligomers 2-5 were determined by interpretation of the spectroscopic data, and the inhibitory activity toward α-glucosidase of all isolates was evaluated. The unusual phloroglcuinol pentamer 5 connected by four methylene linkages showed a much higher potential inhibitory effect against α-glucosidase than the other generated oligomers 2-4 and appeared to be a promising lead for development as a potential antidiabetic agent. Abbreviations: T2DM, type2 diabetes mellitus; DBD, dielectric barrier discharge; HPLC, high-performance liquid chromatography; IC50, 50% inhibition concentration; NMR, nuclear magnetic resonance; FABMS, fastatom bombardment mass spectrometry A new method was developed for simple green synthesis of methylene-bridged phloroglucinol oligomers 2-5 with potent α-glucosidase inhibitory activities using nonthermal.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2018.1516544