Feedback regulation of mitochondrial homeostasis via Wnt/β-catenin signaling

Cellular abundance of mitochondria is dynamically regulated. We could recently show that dysfunctional mitochondria release the phosphatase PGAM family member 5 (PGAM5) into the cytosol, where it interacts with the Wnt signaling-component AXIN1 and dephosphorylates AXIN1-bound β-catenin (CTNNB1) the...

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Bibliographic Details
Published in:Molecular & cellular oncology 2018-05, Vol.5 (3), p.e1458015-e1458015
Main Authors: Bernkopf, Dominic B., Behrens, Jürgen
Format: Article
Language:English
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AXIN1
mitochondria
PGAM5
Wnt signaling
β-catenin
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Summary:Cellular abundance of mitochondria is dynamically regulated. We could recently show that dysfunctional mitochondria release the phosphatase PGAM family member 5 (PGAM5) into the cytosol, where it interacts with the Wnt signaling-component AXIN1 and dephosphorylates AXIN1-bound β-catenin (CTNNB1) thereby activating Wnt/β-catenin signaling. Because Wnt/β-catenin signaling induces mitochondrial biogenesis dysfunctional mitochondria trigger their own replacement by releasing PGAM5.
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2018.1458015