In vitro and in vivo defensive effect of probiotic LAB against Pseudomonas aeruginosa using Caenorhabditis elegans model

This study aimed to investigate in vitro and in vivo the probiotic characteristics of lactic acid bacteria (LAB) isolated from Korean traditional fermented foods. Caenorhabditis elegans  (C. elegans) was used for analytical assays of fertility, chemotaxis, life-span, worm-killing and bacterial colon...

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Bibliographic Details
Published in:Virulence 2018-01, Vol.9 (1), p.1489-1507
Main Authors: Chelliah, Ramachandran, Choi, Jung-Gu, Hwang, Su-bin, Park, Byung-Jae, Daliri, Eric Banan-Mwine, Kim, Se-Hun, Wei, Shuai, Ramakrishnan, Sudha Rani, Oh, Deog-Hwan
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Caenorhabditis elegans (C. elegans)
Caenorhabditis elegans - microbiology
Chemotaxis
Fermented Foods - microbiology
Gastrointestinal Tract - microbiology
Gut colonization
Intestines - microbiology
Korean soybean paste (KSP)
Lactobacillales - physiology
Longevity
Microbial Interactions
Pediococcus - drug effects
Pediococcus - physiology
Pepsin A - pharmacology
Probiotics
Pseudomonas aeruginosa ( PA 14)
Pseudomonas aeruginosa - pathogenicity
Research Paper
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Summary:This study aimed to investigate in vitro and in vivo the probiotic characteristics of lactic acid bacteria (LAB) isolated from Korean traditional fermented foods. Caenorhabditis elegans  (C. elegans) was used for analytical assays of fertility, chemotaxis, life-span, worm-killing and bacterial colonization in the intestinal lumen of the worm. All 35 strains of LAB reduced fertility and slowed development in the worms. The worm-killing assay showed that LAB significantly increased the lifespan (P 
ISSN:2150-5594
2150-5608
DOI:10.1080/21505594.2018.1518088