Arylation of benzyl amines with aromatic nitriles

In the past years, the activations of aromatic nitriles for radical arylations under photoirradiation have been developed. We here report the first example of radical arylations using aromatic nitriles without the assistance of photoirradiation. Importantly, with this method, the direct arylation of...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-10, Vol.54 (84), p.11881-11884
Main Authors: Lei, Yingjie, Yang, Ju, Qi, Rupeng, Wang, Shan, Wang, Rui, Xu, Zhaoqing
Format: Article
Language:English
Subjects:
Amines
Chemical synthesis
Nitriles
Transition metals
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Summary:In the past years, the activations of aromatic nitriles for radical arylations under photoirradiation have been developed. We here report the first example of radical arylations using aromatic nitriles without the assistance of photoirradiation. Importantly, with this method, the direct arylation of C(sp 3 )-H in benzyl amines provided a practical method for the synthesis of diarylmethylamines without the use of precious transition metal catalysts. The C(sp 3 )-H arylation of benzyl amines with aromatic nitriles for the synthesis of diarylmethylamines was realized without the assistance of transition-metal and photoirradiation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc06408c