Laser trapping/confocal Raman spectroscopic characterization of PLGA-PEG nanoparticles

We have immobilized poly(ethylene glycol) (PEG) on the surfaces of poly(lactic- co -glycolic acid) (PLGA) nanoparticles by two different chemical methods, i.e. , SOCl 2 halogenate-alcoholysis and DCC dehydration. The immobilized PLGA nanoparticles were characterized by DLS, 1 H NMR, FT-IR and laser...

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Bibliographic Details
Published in:Soft matter 2018-10, Vol.14 (4), p.89-894
Main Authors: Yang, Jie, Zhang, Ruo-Nan, Liu, Dong-Jie, Zhou, Xu, Shoji, Tatsuya, Tsuboi, Yasuyuki, Yan, Hu
Format: Article
Language:English
Subjects:
Alcoholysis
Aqueous solutions
Dehydration
Fourier transforms
Glycolic acid
Nanoparticles
NMR
Nuclear magnetic resonance
Organic chemistry
Polyethylene glycol
Polylactide-co-glycolide
Raman spectra
Raman spectroscopy
Trapping
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Summary:We have immobilized poly(ethylene glycol) (PEG) on the surfaces of poly(lactic- co -glycolic acid) (PLGA) nanoparticles by two different chemical methods, i.e. , SOCl 2 halogenate-alcoholysis and DCC dehydration. The immobilized PLGA nanoparticles were characterized by DLS, 1 H NMR, FT-IR and laser trapping/confocal Raman spectroscopic techniques. As a result, especially the Raman spectra which were measured after optically trapping ca. 10 individual nanoparticles in solution indicated that the PLGA nanoparticles were successfully immobilized with the PEG by the chemical methods. We have immobilized poly(ethylene glycol) (PEG) on the surfaces of poly(lactic- co -glycolic acid) (PLGA) nanoparticles by two different chemical methods, i.e. , SOCl 2 halogenate-alcoholysis and DCC dehydration. The PEG-immobilized PLGA nanoparticles were precisely characterized by the laser trapping/confocal Raman spectroscope.
ISSN:1744-683X
1744-6848
DOI:10.1039/c8sm01364k