The m 6 A‑methylase complex and mRNA export

During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Gene regulatory mechanisms 2019-03, Vol.1862 (3), p.319
Main Authors: Lesbirel, Simon, Wilson, Stuart A
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus
Adenine - analogs & derivatives
Adenine - metabolism
Animals
Cell Nucleus - metabolism
Exodeoxyribonucleases - metabolism
Humans
Methyltransferases - metabolism
Phosphoproteins - metabolism
RNA Processing, Post-Transcriptional
RNA, Messenger - genetics
RNA, Messenger - metabolism
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Summary:During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N ‑methyladenosine (m A) modification. In this review we discuss the recent evidence of coupling between the m A modification, RNA processing and export.
ISSN:1876-4320