Categorization of endoplasmic reticulum stress as accumulation of unfolded proteins or membrane lipid aberrancy using yeast Ire1 mutants

Endoplasmic reticulum (ER)-located protein Ire1 triggers the unfolded protein response against ER-stressing stimuli, which are categorized as ER accumulation of unfolded proteins or membrane lipid-related aberrancy. Here we demonstrate that by using yeast Ire1 mutants, we can distinguish the categor...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2019-02, Vol.83 (2), p.326-329
Main Authors: Tran, Duc Minh, Takagi, Hiroshi, Kimata, Yukio
Format: Article
Language:English
Subjects:
Basic-Leucine Zipper Transcription Factors - genetics
Basic-Leucine Zipper Transcription Factors - metabolism
Endoplasmic reticulum
Endoplasmic Reticulum Stress
Lipid Metabolism
Membrane Glycoproteins - genetics
Membrane Glycoproteins - metabolism
membrane lipid
Membrane Lipids - metabolism
Mutation
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - metabolism
Proteins - metabolism
Repressor Proteins - genetics
Repressor Proteins - metabolism
RNA, Messenger - genetics
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
stress response
Unfolded Protein Response
UPR
yeast
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Summary:Endoplasmic reticulum (ER)-located protein Ire1 triggers the unfolded protein response against ER-stressing stimuli, which are categorized as ER accumulation of unfolded proteins or membrane lipid-related aberrancy. Here we demonstrate that by using yeast Ire1 mutants, we can distinguish the category to which a stress-inducing stimulus belongs. For instance, ethanol was found to activate Ire1 through both types of cellular damage.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2018.1530098