Lighting up alkaline phosphatase in drug-induced liver injury using a new chemiluminescence resonance energy transfer nanoprobe

We present a new nanoprobe based on chemiluminescence resonance energy transfer for in vivo imaging of drug-induced alkaline phosphatase (ALP). This probe exhibits the perfect degrees of high sensitivity and specificity for real-time monitoring of ALP levels to directly evaluate drug-induced liver i...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (88), p.12479-12482
Main Authors: Liu, Xueting, Fan, Nannan, Wu, Lijie, Wu, Chuanchen, Zhou, Yongqing, Li, Ping, Tang, Bo
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Chemiluminescence
Energy transfer
Liver
Organic chemistry
Phosphatase
Sensitivity analysis
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Summary:We present a new nanoprobe based on chemiluminescence resonance energy transfer for in vivo imaging of drug-induced alkaline phosphatase (ALP). This probe exhibits the perfect degrees of high sensitivity and specificity for real-time monitoring of ALP levels to directly evaluate drug-induced liver injury. Ultra-sensitive imaging of the alkaline phosphatase level in vivo in drug-induced liver injury with a new chemiluminescence resonance energy transfer nanoprobe.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc07211f