A phase II study: dose-dense carboplatin and paclitaxel as neoadjuvant chemotherapy in locally advanced cervical cancer

This study evaluates the efficacy and toxicity of dose-dense weekly paclitaxel and carboplatin as neoadjuvant chemotherapy in locally advanced cervical cancer (LACC). We collected 23 cases of LACC treated with weekly paclitaxel and carboplatin for nine cycles: 20 patients had complete or partial res...

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Bibliographic Details
Published in:Journal of chemotherapy (Florence) 2018-05, Vol.30 (4), p.247-252
Main Authors: Loizzi, Vera, Del Vecchio, Vittoria, Crupano, Francesco M., Minicucci, Valentina, Fumarulo, Valeria V., Resta, Leonardo, Vimercati, Antonella, Bettocchi, Stefano, Cicinelli, Ettore, Cormio, Gennaro
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adenocarcinoma - pathology
Adenocarcinoma - radiotherapy
Adenocarcinoma - surgery
Adult
Aged
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Carboplatin - adverse effects
Carboplatin - therapeutic use
Cervical cancer
Chemotherapy
Female
Humans
Middle Aged
Neoadjuvant
Neoadjuvant Therapy
Neoplasms, Squamous Cell - drug therapy
Neoplasms, Squamous Cell - pathology
Neoplasms, Squamous Cell - radiotherapy
Neoplasms, Squamous Cell - surgery
Paclitaxel - adverse effects
Paclitaxel - therapeutic use
Retrospective Studies
Toxicity
Uterine Cervical Neoplasms - drug therapy
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - radiotherapy
Uterine Cervical Neoplasms - surgery
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Summary:This study evaluates the efficacy and toxicity of dose-dense weekly paclitaxel and carboplatin as neoadjuvant chemotherapy in locally advanced cervical cancer (LACC). We collected 23 cases of LACC treated with weekly paclitaxel and carboplatin for nine cycles: 20 patients had complete or partial response to chemotherapy and were submitted to surgery, 3 with poor response received chemoradiation therapy. Pathologic examination showed complete response in four patients, myometrial invasion 50% in seven patients, parametrial involvement in two, vaginal metastasis in one and lymphovascular space invasion, with positive margins, in another case. Despite seven patients had radiological evidence of lymph nodes involvement at diagnosis, only one had nodal metastases. Five patients showed grade 3-4 of hematologic toxicity.
ISSN:1120-009X
1973-9478
DOI:10.1080/1120009X.2018.1489601