Neuroprotective terpenoids from the leaves of Viburnum odoratissimum

As a part of our ongoing search for neuroprotective compounds from natural products, two new iridoid glycosides, vibsansuspenside A-B (1-2), along with five known terpenoids (3-7), were isolated from the dry leaves of Viburnum odoratissimum. Their chemical structures were well determined by means of...

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Bibliographic Details
Published in:Natural product research 2020-05, Vol.34 (10), p.1352-1359
Main Authors: Zhang, Yan, Zhou, Wei-Yu, Song, Xiao-Yu, Yao, Guo-Dong, Song, Shao-Jiang
Format: Article
Language:English
Subjects:
Annexin V
Apoptosis
Damage
Dopamine receptors
Glycosides
Hydrogen peroxide
Natural products
Neuroblastoma cells
Neuroprotection
neuroprotective activity
NMR
Nuclear magnetic resonance
Terpenes
Terpenoids
Viburnum odoratissimum
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Summary:As a part of our ongoing search for neuroprotective compounds from natural products, two new iridoid glycosides, vibsansuspenside A-B (1-2), along with five known terpenoids (3-7), were isolated from the dry leaves of Viburnum odoratissimum. Their chemical structures were well determined by means of NMR spectroscopic data as well as HRESIMS analysis. All compounds were detected for their neuroprotective effects against H 2 O 2 -induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y). Among them, compound 3 displayed the most potent neuroprotective ability, and further investigation by Annexin V/PI and Western blot analysis demonstrated that compound 3 could protect SH-SY5Y cells from oxidative damage through inhibiting cell apoptosis.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1514400