Antioxidant activity and Neurite outgrowth-enhancing activity of scorbamic acid and a red pigment derived from ascorbic acid

L-Ascorbic acid (AA), known as vitamin C, can form browning products by a non-enzymatic process during storage and the browning products cause deterioration of agricultural products. In the browning reaction, a red pigment, 2,2´-nitrilodi-2(2´)-deoxy-L-ascorbic acid ammonium salt (NDA), is generated...

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Bibliographic Details
Published in:Natural product research 2020-03, Vol.34 (6), p.838-842
Main Authors: Iwaoka, Yuji, Ikeda, Nao, Ohno, Asako, Ito, Hideyuki, Tai, Akihiro
Format: Article
Language:English
Subjects:
2,2´-nitrilodi-2(2´)-deoxy-L-ascorbic acid ammonium salt
Acids
Agricultural products
Ammonium
Ammonium salts
Animals
antioxidant activity
Antioxidants
Antioxidants - pharmacology
Ascorbic acid
Ascorbic Acid - analogs & derivatives
Ascorbic Acid - chemistry
Ascorbic Acid - pharmacology
Axonogenesis
Browning
Coloring Agents
Cyclic AMP
Free Radical Scavengers
L-ascorbic acid
L-scorbamic acid
Maillard Reaction
neurite outgrowth-enhancing activity
Neuronal Outgrowth - drug effects
PC12 Cells
Pheochromocytoma cells
Rats
red pigment
Scavenging
Vitamin C
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Summary:L-Ascorbic acid (AA), known as vitamin C, can form browning products by a non-enzymatic process during storage and the browning products cause deterioration of agricultural products. In the browning reaction, a red pigment, 2,2´-nitrilodi-2(2´)-deoxy-L-ascorbic acid ammonium salt (NDA), is generated from AA via L-scorbamic acid (SCA) as an intermediate. However, the biological activities of SCA and NDA have not yet been clarified. In this study, we assayed the antioxidant activities of SCA and NDA using ABTS radical cation and their neurite outgrowth-enhancing activities in PC12 cells. SCA showed stronger radical-scavenging activity than that of AA, while NDA hardly showed any activity. SCA and NDA enhanced the neurite outgrowth induced by dibutyryl cyclic AMP after their incorporation into cells in the same manner as that of AA. The results indicated that SCA has antioxidant activity and that SCA and NDA have neurite outgrowth-enhancing activity.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1499641