Neoclerodane diterpenoids from Scutellaria barbata with cytotoxic activities

Two new neoclerodane diterpenoids, barbatin F (1), barbatin G (2) together with four known compounds, scutebata A (3), scutebata B (4), scutebata C (5) and scutebata P (6) were isolated from the whole plant of Scutellaria barbata D.Don. Their structures were elucidated on the basis of spectroscopic...

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Bibliographic Details
Published in:Natural product research 2020-05, Vol.34 (10), p.1345-1351
Main Authors: Wang, Maolin, Chen, Yayun, Hu, Peng, Ji, Junyang, Li, Xiang, Chen, Jianwei
Format: Article
Language:English
Subjects:
barbatin F-G
Biotechnology
Cancer
Colon
Colon cancer
Cytotoxicity
cytotoxicity activities
Diterpenes
neoclerodane diterpenoids
Scutellaria barbata
Toxicity
Tumor cell lines
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Summary:Two new neoclerodane diterpenoids, barbatin F (1), barbatin G (2) together with four known compounds, scutebata A (3), scutebata B (4), scutebata C (5) and scutebata P (6) were isolated from the whole plant of Scutellaria barbata D.Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro cytotoxicity of selected compounds against cancer cell lines LoVo, SMMC-7721, HCT-116, and MCF-7 were evaluated, compound 1 and 2 showed weak cytotoxic activities against HCT-116 colon cancer cell lines with IC 50 value of 44.3, 32.3 μM, respectively, while compound 3 and 4 exhibited moderate cytotoxic activities against four tested human cancer cell lines with IC 50 values of 5.31～28.5 μM.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1514399