Pretreatment of simvastatin on liver trace element levels during endotoxemia

There are a number of studies investigating anti-inflammatory effects of simvastatin in patients with sepsis and animal models. There are a few studies which investigated effect of simvastatin on elements in sepsis. In the present study, the impact of pretreatment with simvastatin on element levels...

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Bibliographic Details
Published in:Archives of physiology and biochemistry 2020-05, Vol.126 (3), p.196-200
Main Authors: Yorulmaz, Hatice, Ozkok, Elif, Demir, Goksel, Ertugrul Yalcin, Ibrahim, Ates, Gulten, Olgac, Vakur, Tamer, Sule
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Copper - analysis
Endotoxemia - drug therapy
Hepatocytes - drug effects
Iron - analysis
Lipopolysaccharides - pharmacology
Liver
Liver - drug effects
Magnesium - analysis
Male
Manganese - analysis
Rats
Rats, Wistar
Selenium - analysis
sepsis
simvastatin
Simvastatin - pharmacology
trace elements
Trace Elements - analysis
Zinc - analysis
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Summary:There are a number of studies investigating anti-inflammatory effects of simvastatin in patients with sepsis and animal models. There are a few studies which investigated effect of simvastatin on elements in sepsis. In the present study, the impact of pretreatment with simvastatin on element levels was evaluated in liver during endotoxemia. Rats were divided into control, LPS, simvastatin, and simvastatin + LPS. The histopathologic examination of the liver was performed using hematoxylin and eosin. Selenium, zinc, iron, manganese, magnesium, and copper were analyzed using inductively coupled plasma - optical emission spectroscopy. In the LPS, the hepatocyte cell structure was damaged. In the simvastatin + LPS, hepatocyte, and sinusoidal cord damage were partially smaller than LPS. Levels of selenium, and copper significantly decreased in both of LPS and simvastatin + LPS. In the LPS group, iron was found to increase. In the simvastatin + LPS, zinc was increased. Simvastatin partially smaller liver damage by increasing zinc levels during endotoxemia.
ISSN:1381-3455
1744-4160
DOI:10.1080/13813455.2018.1508234