Association of Anxiety and Depression in Obstructive Sleep Apnea Patients: A Systematic Review and Meta-Analysis

Background: Obstructive sleep apnea (OSA) has been associated with mental disorders, but the strength of this association is unknown. The aim of our study was to investigate the association among OSA, depression, and anxiety in adults and to quantitatively summarize the results. Methods: A literatur...

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Bibliographic Details
Published in:Behavioral sleep medicine 2020-01, Vol.18 (1), p.35-57
Main Authors: Garbarino, Sergio, Bardwell, Wayne A., Guglielmi, Ottavia, Chiorri, Carlo, Bonanni, Enrica, Magnavita, Nicola
Format: Article
Language:English
Subjects:
Adult
Aged
Anxiety
Anxiety - etiology
Bidirectionality
Compliance
Conditioning
Depression - etiology
Evidence-based medicine
Female
Humans
Male
Medical diagnosis
Mental depression
Mental disorders
Meta-analysis
Middle Aged
Obstructive sleep apnea
Sleep apnea
Sleep Apnea, Obstructive - complications
Sleep Apnea, Obstructive - therapy
Systematic review
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Summary:Background: Obstructive sleep apnea (OSA) has been associated with mental disorders, but the strength of this association is unknown. The aim of our study was to investigate the association among OSA, depression, and anxiety in adults and to quantitatively summarize the results. Methods: A literature search in Medline, PubMed, PsycInfo, Scopus, and Web of Science was conducted. Seventy-three articles were selected for study. Results: The pooled prevalence of depressive and anxious symptoms in OSA patients was 35% (95% CI, 28-41%) and 32% (95% CI, 22-42%), respectively. Conclusions: The association between OSA, anxiety, and depression indicates the value of an early diagnosis and personalized treatment of OSA to improve mental disorders conditioning compliance to therapy. These conditions share a probably bidirectional relationship.
ISSN:1540-2002
1540-2010
DOI:10.1080/15402002.2018.1545649