Molecular hydrogen (H2): Potential in mitigating oxidative stress-induced cardiotoxicity

Uncontrolled production of oxygen and nitrogen radicals results in oxidative (OS) and nitrosative (NS) stresses that impair cellular functions and have been regarded as causative common denominators of many pathological processes. In this review, we report on the beneficial effects of molecular hydr...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2018-12
Main Authors: Kura, Branislav, Bagchi, Ashim K, Singal, Pawan K, Barancik, Miroslav, LeBaron, Tyler W, Valachova, Katarina, Soltes, Ladislav, Slezak, Jan
Format: Article
Language:English
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Summary:Uncontrolled production of oxygen and nitrogen radicals results in oxidative (OS) and nitrosative (NS) stresses that impair cellular functions and have been regarded as causative common denominators of many pathological processes. In this review, we report on the beneficial effects of molecular hydrogen (H2) in scavenging radicals in an artificial system of ●OH formation. As a proof of principle, we also demonstrate that in rat hearts in vivo, administration of H2 led to a significant increase in SOD as well as pAKT, a cell survival signaling molecule. Irradiation of the rats caused a significant increase in lipid peroxidation which was mitigated by pre-treatment of the animals with molecular H2. The nuclear factor erythroid 2-related factor 2 (Nrf2) is regarded as an important regulator of oxyradical homeostasis as well as it supports the functional integrity of cells, particularly under conditions of OS. We suggest that the beneficial effects of H2 may be through the activation of Nrf2 pathway that promotes innate antioxidants and reduction of apoptosis as well as inflammation.
ISSN:1205-7541