Maternal serum mitofusin-2 levels in patients with preeclampsia: the possible role of mitochondrial dysfunction in preeclampsia

Purpose: Hypoxia alters mitochondria function and our aim was to measure mitochondrial fusion protein mitofusin-2 (Mfn2) in patients with preeclampsia. Materials and methods: This cross-sectional study was conducted including 82 pregnant women, 27 with normal pregnancy and 55 with preeclampsia (27 w...

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Published in:The journal of maternal-fetal & neonatal medicine 2020-06, Vol.33 (11), p.1861-1866
Main Authors: Aydogan Mathyk, Begum, Temel Yuksel, Ilkbal, Tayyar, Ahmet, Aslan Cetin, Berna, Tayyar, Ahter Tanay, Koroglu, Nadiye
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Case-Control Studies
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
GTP Phosphohydrolases - blood
Humans
Mitochondria
Mitochondria - physiology
mitochondrial fusion
Mitochondrial Proteins - blood
mitofusin-2
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Pre-Eclampsia - etiology
Pre-Eclampsia - physiopathology
preeclampsia
Pregnancy
Stress, Physiological - physiology
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Summary:Purpose: Hypoxia alters mitochondria function and our aim was to measure mitochondrial fusion protein mitofusin-2 (Mfn2) in patients with preeclampsia. Materials and methods: This cross-sectional study was conducted including 82 pregnant women, 27 with normal pregnancy and 55 with preeclampsia (27 with early-onset preeclampsia and 28 with late-onset preeclampsia). Maternal serum levels of Mfn2 were measured by using enzyme-linked immunosorbent assay kits. Results: The mean serum mitofusin-2 levels were higher in women with preeclampsia than in the control group (68.02 ± 8.7 pg/mL vs. 99.72 ± 37.27 pg/mL, p 
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2018.1532497