Chemical constituents from common vetch (Vicia sativa L.) and their antioxidant and cytotoxic activities

Vicia sativa L. (common vetch) is a potential food source for both human beings and animals because of its abundant nutritional composition. There is a lack of phytochemical study on the whole plant, and thus the objective of this study was to investigate the isolation of phytochemicals and evaluate...

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Bibliographic Details
Published in:Natural product research 2020-11, Vol.34 (22), p.3205-3211
Main Authors: Liu, Li-Fang, Li, Wen-Hai, Li, Man-Yu, Wu, Xiao-Zhen, Yang, Fan, Xu, Jia-Nan, Yuan, Cheng-Shan
Format: Article
Language:English
Subjects:
(2R, 3S)-3,3′-dihydroxy-4′,7-dimethoxyflavanol
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Circular Dichroism
Coumarin
cytotoxic activities
Cytotoxicity
Flavanols
Flavones
Flavones - analysis
Food sources
HeLa Cells
HL-60 Cells
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
NMR
Nuclear magnetic resonance
Phytochemicals
Phytochemicals - analysis
Phytochemicals - chemistry
Phytochemicals - pharmacology
Plant Extracts - chemistry
Plant Leaves - chemistry
Plant Stems - chemistry
Scavenging
the DPPH radical scavenging effect
Triterpenes - analysis
Triterpenoids
Tumor cells
Vicia sativa
Vicia sativa - chemistry
Vicia sativa L
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Summary:Vicia sativa L. (common vetch) is a potential food source for both human beings and animals because of its abundant nutritional composition. There is a lack of phytochemical study on the whole plant, and thus the objective of this study was to investigate the isolation of phytochemicals and evaluate their biological activities. A new flavanol, (2R,3S)-3,3′-dihydroxy-4′,7-dimethoxyflavanol (1), together with nine known compounds, two flavones (2-3), one coumarin (4), and six oleanane triterpenoids (5-10), was obtained from Vicia sativa L.. The structure of the new compound 1 was determined via its NMR spectra, IR and CD data. Compound 3 displayed the potential of the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging effect in antioxidant test. In terms of cytotoxic activities, compound 3 showed moderate cytotoxic activities against three human tumor cells, especially HeLa cells.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1560282