Validation of a novel integral disease index for evaluating the grade of activity in Mexican patients with ulcerative colitis: A prospective cohort study

Ulcerative colitis is a chronic condition characterized by inflammation affecting the colon. To objectively and integrally measure disease activity in patients with ulcerative colitis and thus optimize pharmacologic treatment, a novel integral disease index was created that includes the clinical, bi...

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Published in:Revista de gastroenterología de México 2019-07, Vol.84 (3), p.317
Main Authors: Yamamoto-Furusho, J K, Bozada-Gutiérrez, K E, Sánchez-Rodríguez, A, Bojalil-Romano, F, Barreto-Zuñiga, R, Martínez-Benitez, B
Format: Article
Language:eng ; spa
Subjects:
Adult
Aged
Anti-Ulcer Agents - administration & dosage
Anti-Ulcer Agents - therapeutic use
C-Reactive Protein - analysis
Cohort Studies
Colitis, Ulcerative - diagnosis
Colitis, Ulcerative - drug therapy
Colitis, Ulcerative - pathology
Colonoscopy
Defecation
Female
Hemoglobins - analysis
Humans
Male
Mexico
Middle Aged
Prospective Studies
Reproducibility of Results
Serum Albumin - analysis
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container_title Revista de gastroenterología de México
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creator Yamamoto-Furusho, J K
Bozada-Gutiérrez, K E
Sánchez-Rodríguez, A
Bojalil-Romano, F
Barreto-Zuñiga, R
Martínez-Benitez, B
description Ulcerative colitis is a chronic condition characterized by inflammation affecting the colon. To objectively and integrally measure disease activity in patients with ulcerative colitis and thus optimize pharmacologic treatment, a novel integral disease index was created that includes the clinical, biochemical, endoscopic, and histologic characteristics necessary for achieving that task. The aim of the present study was to validate the novel integral disease index in patients with ulcerative colitis. A cohort study on a total of 222 patients with histologic confirmations of ulcerative colitis diagnosis was conducted. The variables included in the disease index were: number of bowel movements per day; values for hemoglobin, high-sensitivity C-reactive protein, and serum albumin; and endoscopic and histologic findings measured through the subscales of the Mayo and Riley scores, respectively. The data analysis was performed utilizing the STATA SE 11.1 statistics program. The correlation of the novel disease index was very good (r=0.817, p
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To objectively and integrally measure disease activity in patients with ulcerative colitis and thus optimize pharmacologic treatment, a novel integral disease index was created that includes the clinical, biochemical, endoscopic, and histologic characteristics necessary for achieving that task. The aim of the present study was to validate the novel integral disease index in patients with ulcerative colitis. A cohort study on a total of 222 patients with histologic confirmations of ulcerative colitis diagnosis was conducted. The variables included in the disease index were: number of bowel movements per day; values for hemoglobin, high-sensitivity C-reactive protein, and serum albumin; and endoscopic and histologic findings measured through the subscales of the Mayo and Riley scores, respectively. The data analysis was performed utilizing the STATA SE 11.1 statistics program. The correlation of the novel disease index was very good (r=0.817, p &lt;.001 with the Truelove and Witts criteria and r=0.957, p &lt;.0001 with the Mayo score, respectively). Good internal consistency was found with a Cronbach's alpha coefficient of 0.78 and an acceptable mean inter-item correlation (r=0.47, p &lt;.05). The total efficacy of the novel index was 87.2% correctly classified patients, with an AUC according to the three scenarios described of 0.93, 0.92, and 0.96, respectively. 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source Elsevier ScienceDirect Journals
subjects Adult
Aged
Anti-Ulcer Agents - administration & dosage
Anti-Ulcer Agents - therapeutic use
C-Reactive Protein - analysis
Cohort Studies
Colitis, Ulcerative - diagnosis
Colitis, Ulcerative - drug therapy
Colitis, Ulcerative - pathology
Colonoscopy
Defecation
Female
Hemoglobins - analysis
Humans
Male
Mexico
Middle Aged
Prospective Studies
Reproducibility of Results
Serum Albumin - analysis
title Validation of a novel integral disease index for evaluating the grade of activity in Mexican patients with ulcerative colitis: A prospective cohort study
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