Lower femoral neck bone mineral density (BMD) in elderly women not on statins

Coronary artery disease (CAD) and osteoporosis, the two most frequently occurring chronic diseases of aging populations, share many risk factors including lack of estrogen, smoking, and low physical activity. CAD and low bone mineral density (BMD) are strongly associated. Statins, (3-hydroxy-3-methy...

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Bibliographic Details
Published in:Women & health 2019-09, Vol.59 (8), p.845-853
Main Authors: Chiadika, Simbo M., Shobayo, Fisayomi O., Naqvi, Syed H., Saraykar, Smita S., Ambrose, Catherine G., Rianon, Nahid J.
Format: Article
Language:English
Subjects:
Aging
Biomedical materials
Bone density
Bone loss
Bone mineral density
Cardiovascular disease
Cardiovascular diseases
Chronic illnesses
Clinical trials
Coenzyme A
Confidence intervals
Coronary artery
Coronary artery disease
coronary artery disease (CAD)
Cross-sectional studies
Disease
elderly
Estrogens
Femur
Geriatrics
Heart diseases
Hydroxymethylglutaryl-CoA reductase
Menopause
Neck
Older people
Osteoporosis
Patients
Physical activity
Physical fitness
Reductases
Risk analysis
Risk factors
Smoking
Statins
Statistical analysis
Women
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Summary:Coronary artery disease (CAD) and osteoporosis, the two most frequently occurring chronic diseases of aging populations, share many risk factors including lack of estrogen, smoking, and low physical activity. CAD and low bone mineral density (BMD) are strongly associated. Statins, (3-hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase inhibitors), are used to prevent and treat CAD and have been associated with high BMD. This cross-sectional study examined associations of BMD with statin use and nonuse in elderly women with or without CAD. Multivariate regression analyses were conducted on 185 women aged ≥60 years who were referred between October 2010 and March 2015 to a geriatric osteoporosis clinic in Houston, Texas, for compromised skeletal health. Compared to the control group (without CAD and without statin use), patients with CAD and no statin use were more likely to have lower femoral neck BMD (β: −0.46, 95% confidence interval: −0.75 to −0.18). The BMD of patients taking statins, regardless of presence of CAD, was similar to that of the control group. Statins may be protective in preventing bone loss in elderly women suffering from CAD. Prospective trials are warranted to determine if continued use of statins in them would help prevent both CAD and bone loss.
ISSN:0363-0242
1541-0331
DOI:10.1080/03630242.2019.1567646