Association of serum uric acid levels with the incident of kidney disease and rapid eGFR decline in Chinese individuals with eGFR > 60 mL/min/1.73 m 2 and negative proteinuria

Epidemiological studies suggest that higher serum uric acid (SUA) level is significantly associated with kidney disease development. However, it remains debatable whether higher SUA is independently associated with new-onset kidney disease and rapid eGFR decline in individuals with estimated glomeru...

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Bibliographic Details
Published in:Clinical and experimental nephrology 2019-07, Vol.23 (7), p.871
Main Authors: Zhou, Fangfang, Yu, Geping, Wang, Guoyu, Liu, Yunzi, Zhang, Liwen, Wang, Weiming, Chen, Nan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers - blood
China - epidemiology
Disease Progression
Female
Glomerular Filtration Rate
Humans
Hyperuricemia - blood
Hyperuricemia - diagnosis
Hyperuricemia - epidemiology
Incidence
Kidney - physiopathology
Kidney Diseases - blood
Kidney Diseases - diagnosis
Kidney Diseases - epidemiology
Kidney Diseases - physiopathology
Male
Middle Aged
Prevalence
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Uric Acid - blood
Young Adult
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Summary:Epidemiological studies suggest that higher serum uric acid (SUA) level is significantly associated with kidney disease development. However, it remains debatable whether higher SUA is independently associated with new-onset kidney disease and rapid eGFR decline in individuals with estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m and negative proteinuria. This was a large, single-center, retrospective 6-year cohort study at People's Hospital of Tonglu County, Zhejiang, from 2001 to 2006. We enrolled 10,677 participants (19-92 years) with eGFR ≥ 60 mL/min/1.73 m and without dipstick proteinuria at baseline. The association between SUA change and the occurrence of renal outcomes and annual eGFR decline were evaluated using Cox models with adjustment for confounders. Higher quartiles (2.51%) of SUA levels were associated with greater prevalence of kidney disease compared with quartile 1 (0.52%), 2 (1.13%) and 3 (1.76%), respectively. In addition, greater baseline SUA levels [OR (95% CI) 3.29(1.68-6.45), p 
ISSN:1437-7799