Effect of two dosages of sodium chloride intake on the blood pressure response to caffeinated coffee in humans in vivo

High sodium intake increases cardiovascular risk by increasing blood pressure. The intake of coffee elevates blood pressure acutely. Preclinical evidence shows that this action of caffeine is enhanced by high salt intake. We hypothesised that high sodium intake augments the acute blood pressure resp...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2019-11, Vol.70 (8), p.1014-1019
Main Authors: Esselink, Anne C., Bril, Lisanne M., Langenhuijsen, Renée W., Bilos, Albert, Riksen, Niels P., Rongen, Gerard A.
Format: Article
Language:English
Subjects:
Adenosine
Adolescent
Adult
Blood pressure
Blood Pressure - drug effects
Caffeine
Caffeine - pharmacology
Cardiovascular diseases
Coffee
Coffee - chemistry
Cross-Over Studies
Female
Food science
Health risk assessment
Health risks
Heart Rate - drug effects
Humans
Hypertension
Male
Primary Prevention
Sodium
Sodium chloride
Sodium Chloride - administration & dosage
Sodium Chloride, Dietary - administration & dosage
Young Adult
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Summary:High sodium intake increases cardiovascular risk by increasing blood pressure. The intake of coffee elevates blood pressure acutely. Preclinical evidence shows that this action of caffeine is enhanced by high salt intake. We hypothesised that high sodium intake augments the acute blood pressure response to coffee in humans. A randomised cross-over study (n = 15) was performed comparing the effect of lower (6 g/d; LS) with higher (12 g/d; HS) sodium chloride diet on blood pressure before and 2 h after regular coffee intake. Baseline blood pressure was 115 ± 4/84 ± 2/68 ± 1 during LS and 121 ± 4/89 ± 2/69 ± 1 mmHg during HS (SBP/Mean Arterial Pressure (MAP)/DBP; mean ± SE, p  0.05 for MAP). Sodium intake does not relevantly modulate the impact of regular coffee consumption on blood pressure.
ISSN:0963-7486
1465-3478
DOI:10.1080/09637486.2019.1595541