68 Ga-PSMA PET thyroid incidentalomas

Thyroid incidentaloma is defined as a thyroid lesion incidentally and newly detected by imaging techniques performed for an unrelated purpose and especially for a non-thyroid disease. The aim of this review is to evaluate the prevalence and clinical significance of focal incidental radiolabelled pro...

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Bibliographic Details
Published in:Hormones (Athens, Greece) Greece), 2019-06, Vol.18 (2), p.145
Main Authors: Bertagna, Francesco, Albano, Domenico, Giovanella, Luca, Bonacina, Mattia, Durmo, Rexhep, Giubbini, Raffaele, Treglia, Giorgio
Format: Article
Language:English
Subjects:
Adenoma - diagnosis
Adenoma - epidemiology
Adenoma - metabolism
Adenoma - pathology
Edetic Acid - analogs & derivatives
Edetic Acid - pharmacokinetics
Humans
Incidental Findings
Male
Oligopeptides - pharmacokinetics
Positron Emission Tomography Computed Tomography - methods
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - epidemiology
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
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Summary:Thyroid incidentaloma is defined as a thyroid lesion incidentally and newly detected by imaging techniques performed for an unrelated purpose and especially for a non-thyroid disease. The aim of this review is to evaluate the prevalence and clinical significance of focal incidental radiolabelled prostate-specific membrane antigen (PSMA) uptake in the thyroid gland [PSMA thyroid incidentaloma (PTI)] revealed by PET/CT or PET/MRI. A comprehensive literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted to find relevant published articles about the prevalence and clinical significance of PTIs detected by PET/CT or PET/MRI in patients studied for other oncologic purposes. Twelve articles were included in the systematic review. Among 23 PTIs, 6 were malignant (5 primary thyroid tumors and one metastasis from renal cell carcinoma), one was a follicular lesion of undetermined significance, and the rest were benign. Despite being very rare, though probably underestimated, PTIs frequently signal the presence of unexpected lesions in the thyroid which differ from the indicated reason for which the patient was initially scanned and concerning which the risk of malignancy is not negligible.
ISSN:2520-8721
DOI:10.1007/s42000-019-00106-8