Assessment of the risk factors associated with multidrug resistance tuberculosis in Sudan: a case control study

• Published in: Epidemiology and health 2019-04, p.e2019014
• Main Authors: Elduma, Adel Hussein, Mansournia, Mohammad Ali, Foroushani, Abbas Rahimi, Ali, Hamdan Mustafa Hamdan, Salam Elegail, Asrar M A, Asma Elsony, Asma, Holakouie-Naieni, Kourosh
• Format: Article
• Language: English
• ISSN: 2092-7193

Emerging of multidrug resistant tuberculosis (MDR-TB) is considered as a major challenge to control TB globally. The aim of this study is to determine the risk factors associated with MDR-TB in Sudan. This is a case control study began in May 2017 and finished in February 2019. New MDR-TB was selected as cases, and controls were selected from tuberculosis patients who respond to first line anti-tuberculosis drugs. A designed questionnaire was used to collect data from study participants. Logistic regression was used to evaluate the association between risk factors and infection with MDR-TB. Best multivariable model was selected based on the likelihood ratio test. A total number of 430 cases and 860 controls were selected for this study. The adjusted odd ratio (AOR) showed that history of previous TB treatment (AOR = 54.8; 95% CI, 30.48 to 98.69) was strongly association with MDR-TB infection. We identified stop TB treatment (AOR = 7.6; 95% CI, 3.16 to 18.34), contact with MDR-TB patients (AOR =5.4; 95% CI, 2.69 to 10.74), decreased body weight (AOR = 0.8; 95% CI, 0.87 to 0.91), and water pipe smocking (AOR= 3.2; 95% CI, 1.73 to 6.04) were associated with MDR-TB infection. History of TB treatment, stop TB treatment, contacts with MDR-TB patient, water pipe smoking were associated with the MDR-TB infection in Sudan. More efforts are required to decrease the rate of default, strengthening patient adherence to treatment, and prevention measures among MDR-TB contact.