Evaluation of Antimicrobial Properties of Conventional Poly(Methyl Methacrylate) Denture Base Resin Materials Containing Hydrothermally Synthesised Anatase TiO 2 Nanotubes against Cariogenic Bacteria and Candida albicans

• Published in: Iranian journal of pharmaceutical research : IJPR 2018, Vol.17 (Suppl2), p.161
• Main Authors: Abdulrazzaq Naji, Sahar, Jafarzadeh Kashi, Tahereh Sadat, Pourhajibagher, Maryam, Behroozibakhsh, Marjan, Masaeli, Reza, Bahador, Abbas
• Format: Article
• Language: English
• ISSN: 1735-0328

The purpose of this study was to investigate the antimicrobial properties of a conventional poly methyl methacrylate (PMMA) modified with hydrothermally synthesised titanium dioxide nanotubes (TNTs). Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentrations (MFC) for planktonic cells of the TiO nanotubes solution against and were determined. The powder of conventional acrylic resin was modified using 2.5% and 5% by weight synthesised titanium dioxide (TiO ) nanotubes, and rectangular-shaped specimens (10 mm × 10 mm × 3 mm) were fabricated. The antimicrobial properties of ultraviolet (UV) and non-UV irradiated modified, and non-modified acrylic resins were evaluated using the estimation of planktonic cell count and biofilm formation of the three microorganisms mentioned above. The data were analysed by one-way analysis of variance (ANOVA), followed by a post-hoc Tukey's test at a significance level of 5%. MIC, for , , and , MBC for and and MFC for were obtained more than 2100 µg/mL. The results of this study indicated a significant reduction in both planktonic cell count and biofilm formation of modified UV-activated acrylic specimens compared with the control group ( 0.00). According to the results of the current study, it can be concluded that PMMA/TiO nanotube composite can be considered as a promising new material for antimicrobial approaches.