Antiproliferative effects of new magnetic pH-responsive drug delivery system composed of Fe 3 O 4 , CaAl layered double hydroxide and levodopa on melanoma cancer cells

In this study, an efficient drug delivery system composed of Fe O , CaAl layered double hydroxide (LDH) and l-Dopa has been synthesized through hydrogen bonds between l-Dopa and CaAl-LDH encapsulated Fe O nanoparticles (Fe O @CaAl-LDH@l-Dopa). The structural features of Fe O @CaAl-LDH@l-Dopa were ch...

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Bibliographic Details
Published in:Materials science & engineering. C, Materials for biological applications Materials for biological applications, 2019-08, Vol.101, p.472
Main Authors: Shahabadi, Nahid, Razlansari, Mahtab, Zhaleh, Hossein, Mansouri, Kamran
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Death - drug effects
Cell Line, Tumor
Cell Proliferation - drug effects
Drug Carriers - chemistry
Drug Delivery Systems - methods
Humans
Hydrogen-Ion Concentration
Hydroxides - chemistry
Hydroxides - pharmacology
Levodopa - chemistry
Levodopa - pharmacology
Melanoma - metabolism
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Summary:In this study, an efficient drug delivery system composed of Fe O , CaAl layered double hydroxide (LDH) and l-Dopa has been synthesized through hydrogen bonds between l-Dopa and CaAl-LDH encapsulated Fe O nanoparticles (Fe O @CaAl-LDH@l-Dopa). The structural features of Fe O @CaAl-LDH@l-Dopa were characterized using XRD, SEM, TEM, EDX, FT-IR, VSM, TGA, XPS, zeta potential analysis and BET. All of the characterization techniques show the uniform high surface area core-shell structure with about 120 nm in average size. Also, the obtained results clearly indicate that this drug delivery system possess high potent for adsorption of l-Dopa (52 wt%) and high drug encapsulation efficiency (71%). The amount of l-Dopa release in low pHs (53.8%) which simulates the environment of cancer cells is greater than higher pHs. The in vitro cytotoxic and anticancer activities of Fe O @CaAl-LDH@l-Dopa were investigated against Mel-Rm Cells Melanoma (NCIt: C3224) using LDH colorimetric assay and differential staining cell death assay. The results showed Fe O @CaAl-LDH@l-Dopa with a lower concentration of l-Dopa, illustrate a higher cytotoxicity and anticancer activity.
ISSN:1873-0191
DOI:10.1016/j.msec.2019.04.004