Liver MR relaxometry at 3T - segmental normal T 1 and T 2 values in patients without focal or diffuse liver disease and in patients with increased liver fat and elevated liver stiffness

Magnetic resonance (MR) T and T * mapping allows quantification of liver relaxation times for non-invasive characterization of diffuse liver disease. We hypothesized that liver relaxation times are not only influenced by liver fibrosis, inflammation and fat, but also by air in liver segments adjacen...

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Bibliographic Details
Published in:Scientific reports 2019-05, Vol.9 (1), p.8106
Main Authors: Obmann, V C, Mertineit, N, Marx, C, Berzigotti, A, Ebner, L, Heverhagen, J T, Christe, A, Huber, A T
Format: Article
Language:English
Subjects:
Aged
Fatty Liver - diagnostic imaging
Fatty Liver - metabolism
Fatty Liver - pathology
Female
Humans
Liver - diagnostic imaging
Liver - pathology
Liver Diseases - diagnostic imaging
Liver Diseases - metabolism
Liver Diseases - pathology
Lung - diagnostic imaging
Lung - metabolism
Lung - pathology
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Middle Aged
Protons
Relaxation - physiology
Risk Factors
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Summary:Magnetic resonance (MR) T and T * mapping allows quantification of liver relaxation times for non-invasive characterization of diffuse liver disease. We hypothesized that liver relaxation times are not only influenced by liver fibrosis, inflammation and fat, but also by air in liver segments adjacent to the lung - especially in MR imaging at 3T. A total of 161 study participants were recruited, while 6 patients had to be excluded due to claustrophobia or technically uninterpretable MR elastography. Resulting study population consisted of 12 healthy volunteers and 143 patients who prospectively underwent multiparametric MR imaging at 3T. Of those 143 patients, 79 had normal liver stiffness in MR elastography (shear modulus
ISSN:2045-2322