A recyclable post-synthetically modified Al() based metal-organic framework for fast and selective fluorogenic recognition of bilirubin in human biofluids

Herein, we report the fast and selective detection of bilirubin by a recyclable Al( iii ) based post-synthetically modified MIL-53 metal-organic framework (MOF) ( 1-NH 2 @THB ). Post-synthetic modification was achieved by the aldimine condensation reaction between MIL-53-NH 2 and 2,3,4-trihydroxy be...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2019-06, Vol.48 (25), p.9266-9275
Main Authors: Nandi, Soutick, Biswas, Shyam
Format: Article
Language:English
Subjects:
Aluminum
Benzaldehyde
Biomolecules
Condensates
Digital imaging
Fluorescence
Fourier transforms
Infrared analysis
Infrared spectroscopy
Metal-organic frameworks
Molecular interactions
NMR
Nuclear magnetic resonance
Portable equipment
Quenching
Selectivity
Spectra
Spectrum analysis
Urine
X ray powder diffraction
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Summary:Herein, we report the fast and selective detection of bilirubin by a recyclable Al( iii ) based post-synthetically modified MIL-53 metal-organic framework (MOF) ( 1-NH 2 @THB ). Post-synthetic modification was achieved by the aldimine condensation reaction between MIL-53-NH 2 and 2,3,4-trihydroxy benzaldehyde. The post-synthetically modified compound was successfully characterized by Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric (TG) analysis and X-ray powder diffraction (XRPD) experiments. The material has huge potential to detect bilirubin in HEPES buffer medium (pH = 7.4) by a fluorescence "turn-off" mechanism. The drastic quenching in the fluorescence emission intensity of the MOF material in the presence of bilirubin is due to the inner filter effect as well as molecular interactions between the MOF material and bilirubin. The probe displayed ultra-fast response (30 s), low detection limit (1.26 pM) and high selectivity towards bilirubin with the co-existence of several metal ions and biomolecules. Moreover, the real field application of the probe was thoroughly investigated in human bio-fluids (blood serum and urine samples) by the standard addition method. Furthermore, the quenching ability of the MOF material by bilirubin was also explored on a portable paper strip device. All the above discussions indicate that the probe is a potential candidate for the clinical detection of jaundice. The ultra-fast, highly sensitive and selective sensing features of bilirubin in human biofluids by a post-synthetically modified Al( iii ) MOF are presented.
ISSN:1477-9226
1477-9234
DOI:10.1039/c9dt01180c