A Wireless Handheld Pressure Measurement System for In Vivo Monitoring of Intraocular Pressure in Rabbits

Intraocular pressure (IOP) is the leading modifiable risk factor for preventing vision loss in glaucoma patients. Direct and frequent IOP measurements are highly desirable to assess adequacy of treatment and prevent further vision loss. In this study, we report on successful in vivo measurements of...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2020-03, Vol.67 (3), p.931-937
Main Authors: Phan, Alex, Truong, Phuong, Camp, Andrew, Stewart, Kerrianne, Suen, Benjamin, Weinreb, Robert N., Talke, Frank E.
Format: Article
Language:English
Subjects:
Adequacy
Animals
Biocompatibility
Biofouling
Biomedical measurement
Biomedical Research
Bonding
Cataracts
Equipment Design
Glaucoma
Implantation
In vivo methods and tests
Interferometry
Intraocular pressure
Intraocular Pressure - physiology
Intraocular pressure sensor
Lenses
Light sources
measurement system
Optical interferometry
Patients
Pressure
Pressure measurement
Rabbits
reader
Risk analysis
Risk factors
Sensors
Single lens reflex
Substrates
Surgery
Surgical implants
Tonometry, Ocular - instrumentation
Vision
Wireless Technology - instrumentation
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Summary:Intraocular pressure (IOP) is the leading modifiable risk factor for preventing vision loss in glaucoma patients. Direct and frequent IOP measurements are highly desirable to assess adequacy of treatment and prevent further vision loss. In this study, we report on successful in vivo measurements of intraocular pressure in rabbits using an optical IOP measurement system. The sensor was implanted during cataract surgery in two New Zealand white (NZW) rabbits and tested in vivo for ten weeks. Prior to implantation, the sensors were characterized in vitro in the physiologically relevant pressure range of 0-60 mmHg. A portable wireless handheld reader consisting of an internal beam splitter, a monochromatic light source, and a digital single-lens reflex (DSLR) camera was also designed and implemented to capture interference patterns from the sensor. The sensitivity and accuracy of the sensor was 30 nm/mmHg and ±0.2 mmHg, respectively. Ten weeks post-implantation, the two NZW rabbits continued to respond well to the implant with no observable inflammation, signs of infection, or biofouling. All IOP measurements were obtained using the portable DSLR handheld reader. Successful in vivo studies demonstrate biocompatibility of the IOP sensor and prove feasibility of the IOP measurement system. The system has the potential to be used in both clinical and patient point-of-care (home) settings to frequently and accurately measure pressure.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2019.2924440