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A near-infrared biothiol-specific fluorescent probe for cancer cell recognition
Cancer is a global health issue and a leading cause of death. The discrimination of cancer cells from normal cells is of significant importance for the early diagnosis of cancers. As one of the useful biomarkers for developing cancer diagnosis and chemotherapy resistance systems, biothiols not only...
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| Published in: | Analyst (London) 2019-08, Vol.144 (16), p.475-4756 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
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| cites | cdi_FETCH-LOGICAL-c425t-ee8559c770a636add1f03fb0e1fdd5e84332d293a81f8f89b5a6dd8457199e6b3 |
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| container_issue | 16 |
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| container_title | Analyst (London) |
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| creator | Liu, Li Lv, Rui-Jie Leung, Jong-Kai Zou, Qian Wang, Yue Li, Fei Liang, Wang Feng, Shun Wu, Ming-Yu |
| description | Cancer is a global health issue and a leading cause of death. The discrimination of cancer cells from normal cells is of significant importance for the early diagnosis of cancers. As one of the useful biomarkers for developing cancer diagnosis and chemotherapy resistance systems, biothiols not only play an essential role in physiological and pathological processes but also exhibit cytoprotective effects in the susceptibility to carcinogenesis. It would be highly desirable to explore near-infrared biothiol-specific fluorescent probes for cancer diagnosis with outstanding specificity. In this study, a novel near-infrared fluorescent probe
BPO-THAZ
decorated with thiazole as a recognition site was presented for sensitive and selective detection of endogenous biothiols.
BPO-THAZ
can be used to not only evaluate the biothiol level in living HeLa cells upon treatment with H
2
O
2
or anti-cancer drugs but also assess endogenous biothiols in stem cells. Furthermore,
BPO-THAZ
was successfully utilized to discriminate cancer cells from normal cells showing great promise for cancer diagnosis.
A novel near-infrared biothiol-specific fluorescent probe can discriminate cancer cells from normal cells showing great promise for cancer diagnosis. |
| doi_str_mv | 10.1039/c9an00795d |
| format | article |
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BPO-THAZ
decorated with thiazole as a recognition site was presented for sensitive and selective detection of endogenous biothiols.
BPO-THAZ
can be used to not only evaluate the biothiol level in living HeLa cells upon treatment with H
2
O
2
or anti-cancer drugs but also assess endogenous biothiols in stem cells. Furthermore,
BPO-THAZ
was successfully utilized to discriminate cancer cells from normal cells showing great promise for cancer diagnosis.
A novel near-infrared biothiol-specific fluorescent probe can discriminate cancer cells from normal cells showing great promise for cancer diagnosis.</description><identifier>ISSN: 0003-2654</identifier><identifier>ISSN: 1364-5528</identifier><identifier>EISSN: 1364-5528</identifier><identifier>DOI: 10.1039/c9an00795d</identifier><identifier>PMID: 31282915</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Biomarkers ; Biomarkers, Tumor - analysis ; Cancer ; Carcinogens ; Cell Line, Tumor ; Chemotherapy ; Diagnosis ; Embryonic Stem Cells ; Fluoresceins - chemical synthesis ; Fluoresceins - chemistry ; Fluoresceins - toxicity ; Fluorescent Dyes - chemical synthesis ; Fluorescent Dyes - chemistry ; Fluorescent Dyes - toxicity ; Fluorescent indicators ; Humans ; Hydrogen peroxide ; Limit of Detection ; Medical diagnosis ; Medicin och hälsovetenskap ; Mice ; Microscopy, Confocal - methods ; Microscopy, Fluorescence - methods ; Near infrared radiation ; NIH 3T3 Cells ; NMR ; Nuclear magnetic resonance ; Physiological effects ; Pluripotent Stem Cells ; Recognition ; Stem cells ; Sulfhydryl Compounds - analysis ; Thiazoles - chemical synthesis ; Thiazoles - chemistry ; Thiazoles - toxicity</subject><ispartof>Analyst (London), 2019-08, Vol.144 (16), p.475-4756</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-ee8559c770a636add1f03fb0e1fdd5e84332d293a81f8f89b5a6dd8457199e6b3</citedby><cites>FETCH-LOGICAL-c425t-ee8559c770a636add1f03fb0e1fdd5e84332d293a81f8f89b5a6dd8457199e6b3</cites><orcidid>0000-0002-7930-5485 ; 0000-0002-2047-3441</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31282915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:141776658$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Lv, Rui-Jie</creatorcontrib><creatorcontrib>Leung, Jong-Kai</creatorcontrib><creatorcontrib>Zou, Qian</creatorcontrib><creatorcontrib>Wang, Yue</creatorcontrib><creatorcontrib>Li, Fei</creatorcontrib><creatorcontrib>Liang, Wang</creatorcontrib><creatorcontrib>Feng, Shun</creatorcontrib><creatorcontrib>Wu, Ming-Yu</creatorcontrib><title>A near-infrared biothiol-specific fluorescent probe for cancer cell recognition</title><title>Analyst (London)</title><addtitle>Analyst</addtitle><description>Cancer is a global health issue and a leading cause of death. The discrimination of cancer cells from normal cells is of significant importance for the early diagnosis of cancers. As one of the useful biomarkers for developing cancer diagnosis and chemotherapy resistance systems, biothiols not only play an essential role in physiological and pathological processes but also exhibit cytoprotective effects in the susceptibility to carcinogenesis. It would be highly desirable to explore near-infrared biothiol-specific fluorescent probes for cancer diagnosis with outstanding specificity. In this study, a novel near-infrared fluorescent probe
BPO-THAZ
decorated with thiazole as a recognition site was presented for sensitive and selective detection of endogenous biothiols.
BPO-THAZ
can be used to not only evaluate the biothiol level in living HeLa cells upon treatment with H
2
O
2
or anti-cancer drugs but also assess endogenous biothiols in stem cells. Furthermore,
BPO-THAZ
was successfully utilized to discriminate cancer cells from normal cells showing great promise for cancer diagnosis.
A novel near-infrared biothiol-specific fluorescent probe can discriminate cancer cells from normal cells showing great promise for cancer diagnosis.</description><subject>Animals</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Cancer</subject><subject>Carcinogens</subject><subject>Cell Line, Tumor</subject><subject>Chemotherapy</subject><subject>Diagnosis</subject><subject>Embryonic Stem Cells</subject><subject>Fluoresceins - chemical synthesis</subject><subject>Fluoresceins - chemistry</subject><subject>Fluoresceins - toxicity</subject><subject>Fluorescent Dyes - chemical synthesis</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Fluorescent Dyes - toxicity</subject><subject>Fluorescent indicators</subject><subject>Humans</subject><subject>Hydrogen peroxide</subject><subject>Limit of Detection</subject><subject>Medical diagnosis</subject><subject>Medicin och hälsovetenskap</subject><subject>Mice</subject><subject>Microscopy, Confocal - methods</subject><subject>Microscopy, Fluorescence - methods</subject><subject>Near infrared radiation</subject><subject>NIH 3T3 Cells</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Physiological effects</subject><subject>Pluripotent Stem Cells</subject><subject>Recognition</subject><subject>Stem cells</subject><subject>Sulfhydryl Compounds - analysis</subject><subject>Thiazoles - chemical synthesis</subject><subject>Thiazoles - chemistry</subject><subject>Thiazoles - toxicity</subject><issn>0003-2654</issn><issn>1364-5528</issn><issn>1364-5528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kctPxCAQxonR6Pq4eNc08WZS5VEoHDfrMzF60XNDYVC0lhXaGP970X148jQw8_tmMvMhdEjwGcFMnRule4xrxe0GmhAmqpJzKjfRBGPMSip4tYN2U3rNX4I53kY7jFBJFeET9DAtetCx9L2LOoItWh-GFx-6Ms3BeOdN4boxREgG-qGYx9BC4UIsjO4N5ABdV0Qw4bn3gw_9PtpyuktwsIx76Onq8nF2U949XN_OpnelqSgfSgDJuTJ1jbVgQltLHGauxUCctRxkxRi1VDEtiZNOqpZrYa2seE2UAtGyPVQu-qZPmI9tM4_-XcevJmjfLFNv-QVNVedJOPPqXz4vZf9EKyGpSF0LwWXWniy0GfwYIQ3Naxhjn9drKBX5kIJJmqnTBWViSCmCW88guPnxqZmp6f2vTxcZPl62HNt3sGt0ZUwGjhZATGZd_TOafQPTQpjn</recordid><startdate>20190805</startdate><enddate>20190805</enddate><creator>Liu, Li</creator><creator>Lv, Rui-Jie</creator><creator>Leung, Jong-Kai</creator><creator>Zou, Qian</creator><creator>Wang, Yue</creator><creator>Li, Fei</creator><creator>Liang, Wang</creator><creator>Feng, Shun</creator><creator>Wu, Ming-Yu</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>ADTPV</scope><scope>AOWAS</scope><orcidid>https://orcid.org/0000-0002-7930-5485</orcidid><orcidid>https://orcid.org/0000-0002-2047-3441</orcidid></search><sort><creationdate>20190805</creationdate><title>A near-infrared biothiol-specific fluorescent probe for cancer cell recognition</title><author>Liu, Li ; Lv, Rui-Jie ; Leung, Jong-Kai ; Zou, Qian ; Wang, Yue ; Li, Fei ; Liang, Wang ; Feng, Shun ; Wu, Ming-Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-ee8559c770a636add1f03fb0e1fdd5e84332d293a81f8f89b5a6dd8457199e6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Cancer</topic><topic>Carcinogens</topic><topic>Cell Line, Tumor</topic><topic>Chemotherapy</topic><topic>Diagnosis</topic><topic>Embryonic Stem Cells</topic><topic>Fluoresceins - chemical synthesis</topic><topic>Fluoresceins - chemistry</topic><topic>Fluoresceins - toxicity</topic><topic>Fluorescent Dyes - chemical synthesis</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Fluorescent Dyes - toxicity</topic><topic>Fluorescent indicators</topic><topic>Humans</topic><topic>Hydrogen peroxide</topic><topic>Limit of Detection</topic><topic>Medical diagnosis</topic><topic>Medicin och hälsovetenskap</topic><topic>Mice</topic><topic>Microscopy, Confocal - methods</topic><topic>Microscopy, Fluorescence - methods</topic><topic>Near infrared radiation</topic><topic>NIH 3T3 Cells</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Physiological effects</topic><topic>Pluripotent Stem Cells</topic><topic>Recognition</topic><topic>Stem cells</topic><topic>Sulfhydryl Compounds - analysis</topic><topic>Thiazoles - chemical synthesis</topic><topic>Thiazoles - chemistry</topic><topic>Thiazoles - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Lv, Rui-Jie</creatorcontrib><creatorcontrib>Leung, Jong-Kai</creatorcontrib><creatorcontrib>Zou, Qian</creatorcontrib><creatorcontrib>Wang, Yue</creatorcontrib><creatorcontrib>Li, Fei</creatorcontrib><creatorcontrib>Liang, Wang</creatorcontrib><creatorcontrib>Feng, Shun</creatorcontrib><creatorcontrib>Wu, Ming-Yu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Analyst (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Li</au><au>Lv, Rui-Jie</au><au>Leung, Jong-Kai</au><au>Zou, Qian</au><au>Wang, Yue</au><au>Li, Fei</au><au>Liang, Wang</au><au>Feng, Shun</au><au>Wu, Ming-Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A near-infrared biothiol-specific fluorescent probe for cancer cell recognition</atitle><jtitle>Analyst (London)</jtitle><addtitle>Analyst</addtitle><date>2019-08-05</date><risdate>2019</risdate><volume>144</volume><issue>16</issue><spage>475</spage><epage>4756</epage><pages>475-4756</pages><issn>0003-2654</issn><issn>1364-5528</issn><eissn>1364-5528</eissn><abstract>Cancer is a global health issue and a leading cause of death. The discrimination of cancer cells from normal cells is of significant importance for the early diagnosis of cancers. As one of the useful biomarkers for developing cancer diagnosis and chemotherapy resistance systems, biothiols not only play an essential role in physiological and pathological processes but also exhibit cytoprotective effects in the susceptibility to carcinogenesis. It would be highly desirable to explore near-infrared biothiol-specific fluorescent probes for cancer diagnosis with outstanding specificity. In this study, a novel near-infrared fluorescent probe
BPO-THAZ
decorated with thiazole as a recognition site was presented for sensitive and selective detection of endogenous biothiols.
BPO-THAZ
can be used to not only evaluate the biothiol level in living HeLa cells upon treatment with H
2
O
2
or anti-cancer drugs but also assess endogenous biothiols in stem cells. Furthermore,
BPO-THAZ
was successfully utilized to discriminate cancer cells from normal cells showing great promise for cancer diagnosis.
A novel near-infrared biothiol-specific fluorescent probe can discriminate cancer cells from normal cells showing great promise for cancer diagnosis.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>31282915</pmid><doi>10.1039/c9an00795d</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7930-5485</orcidid><orcidid>https://orcid.org/0000-0002-2047-3441</orcidid></addata></record> |
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| ispartof | Analyst (London), 2019-08, Vol.144 (16), p.475-4756 |
| issn | 0003-2654 1364-5528 1364-5528 |
| language | eng |
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| source | Royal Society of Chemistry |
| subjects | Animals Biomarkers Biomarkers, Tumor - analysis Cancer Carcinogens Cell Line, Tumor Chemotherapy Diagnosis Embryonic Stem Cells Fluoresceins - chemical synthesis Fluoresceins - chemistry Fluoresceins - toxicity Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - toxicity Fluorescent indicators Humans Hydrogen peroxide Limit of Detection Medical diagnosis Medicin och hälsovetenskap Mice Microscopy, Confocal - methods Microscopy, Fluorescence - methods Near infrared radiation NIH 3T3 Cells NMR Nuclear magnetic resonance Physiological effects Pluripotent Stem Cells Recognition Stem cells Sulfhydryl Compounds - analysis Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - toxicity |
| title | A near-infrared biothiol-specific fluorescent probe for cancer cell recognition |
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