Determining dose enhancement factors of high-Z nanoparticles from simulations where lateral secondary particle disequilibrium exists

Nanoparticles (NPs) containing high atomic number (high-Z) materials have been shown to enhance the radiobiological effectiveness of ionizing radiation. This effect is often attributed to an enhancement of the absorbed dose in the vicinity of the NPs, based on Monte Carlo simulations that show a sig...

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Bibliographic Details
Published in:Physics in medicine & biology 2019-08, Vol.64 (15), p.155016-155016
Main Authors: Rabus, Hans, Gargioni, Elisabetta, Li, Wei Bo, Nettelbeck, Heidi, Villagrasa, Carmen
Format: Article
Language:English
Subjects:
Computer Simulation
dose enhancement
Gold - chemistry
gold nanoparticles
high
Humans
Metal Nanoparticles - chemistry
Metal Nanoparticles - radiation effects
Monte Carlo Method
Monte Carlo simulation
nanoparticles
Photons
Physics
Radiation Dosage
Radiation-Sensitizing Agents - chemistry
Radiation-Sensitizing Agents - radiation effects
secondary electron equilibrium
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Summary:Nanoparticles (NPs) containing high atomic number (high-Z) materials have been shown to enhance the radiobiological effectiveness of ionizing radiation. This effect is often attributed to an enhancement of the absorbed dose in the vicinity of the NPs, based on Monte Carlo simulations that show a significant local enhancement of the energy deposition on the microscopic scale. The results of such simulations may be significantly biased and lead to a severe overestimation of the dose enhancement if the condition of secondary particle equilibrium is not met in the simulation setup. This current work shows an approach to estimate a 'realistic' dose enhancement from the results of such biased simulations which is based on published photon interaction data and provides a way for correcting biased results.
ISSN:0031-9155
1361-6560
DOI:10.1088/1361-6560/ab31d4