Diagnostic and grading accuracy of 18 F-FDOPA PET and PET/CT in patients with gliomas: a systematic review and meta-analysis

Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[ F] fluoro-L-phenylalanine ( F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analysis to obtain the diagnostic and grading accuracy of F-FDOPA PET and PET/CT in patients wit...

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Bibliographic Details
Published in:BMC cancer 2019-08, Vol.19 (1), p.767
Main Authors: Xiao, Jiarui, Jin, Yizi, Nie, Ji, Chen, Fukun, Ma, Xuelei
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Brain Neoplasms - diagnostic imaging
Child
Data Accuracy
Female
Fluorine Radioisotopes
Formycins
Glioma - diagnostic imaging
Humans
Male
Middle Aged
Neoplasm Grading
Neoplasm Recurrence, Local - diagnostic imaging
Positron Emission Tomography Computed Tomography - methods
Positron-Emission Tomography - methods
Publication Bias
Radiopharmaceuticals
Ribonucleotides
ROC Curve
Sensitivity and Specificity
Young Adult
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Summary:Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[ F] fluoro-L-phenylalanine ( F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analysis to obtain the diagnostic and grading accuracy of F-FDOPA PET and PET/CT in patients with gliomas. PubMed, Embase, Cochrane Library and Web of Science were searched through 13 May 2019. We included studies reporting the diagnostic performance of F-FDOPA PET or PET/CT in glioma patients. Pooled sensitivity, specificity, and area under the summary receiver operating characteristic (SROC) curve were calculated from eligible studies on a per-lesion basis. Eventually, 19 studies were included. Across 13 studies (370 patients) for glioma diagnosis, the pooled sensitivity and specificity of F-FDOPA PET and PET/CT were 0.90 (95%CI: 0.86-0.93) and 0.75 (95%CI: 0.65-0.83). Across 7 studies (219 patients) for glioma grading, F-FDOPA PET and PET/CT showed a pooled sensitivity of 0.88 (95%CI: 0.81-0.93) and a pooled specificity of 0.73 (95%CI: 0.64-0.81). F-FDOPA PET and PET/CT demonstrated good performance for diagnosing gliomas and differentiating high-grade gliomas (HGGs) from low-grade gliomas (LGGs). Further studies implementing standardized PET protocols and investigating the grading parameters are needed.
ISSN:1471-2407