Graphene coated gold nanoparticles: an emerging class of nanoagents for photothermal therapy applications

Graphene coated gold nanoparticles (GGNPs) have attracted great attention in recent years because of their high thermal stability and unique optical properties. In this paper, we study photothermal properties of GGNPs using the Mie and Gans theories combined with the Pennes bioheat equation. The eff...

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Bibliographic Details
Published in:Physical chemistry chemical physics : PCCP 2019, Vol.21 (33), p.18352-18362
Main Authors: Farokhnezhad, Mohsen, Esmaeilzadeh, Mahdi
Format: Article
Language:English
Subjects:
Aspect ratio
Coating
Extinction
Gold
Graphene
High temperature
Nanoparticles
Nanorods
Nanospheres
Optical properties
Temperature distribution
Therapy
Thermal stability
Tumors
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Summary:Graphene coated gold nanoparticles (GGNPs) have attracted great attention in recent years because of their high thermal stability and unique optical properties. In this paper, we study photothermal properties of GGNPs using the Mie and Gans theories combined with the Pennes bioheat equation. The effect of various sizes and different shapes of GGNPs such as nanosphere, nanorod and nanodisc are taken into account. The extinction efficiency and temperature distribution in tumor tissue show that graphene coated gold nanorods, because of the high temperature rise during laser irradiation, are more suitable candidates for photothermal therapy (PTT) applications. Also, we show that the extinction peak of graphene coated gold nanorods can be adjusted in the biological windows by increasing the graphene shell thickness and/or by changing their aspect ratio. Finally, we investigated the effect of the number of graphene layers upon the temperature rise in the tumor and found that the temperature rise increases with increasing number of graphene layers. Our findings introduce a new class of nanoagents which can be used in PTT applications. Optical and photothermal properties of graphene coated gold nanoparticles show that these nanoparticles are more suitable candidates for photothermal therapy applications.
ISSN:1463-9076
1463-9084
DOI:10.1039/c9cp03126j