Ultrasonic energy-assisted in-situ synthesis of Ru 0 /PANI/g-C 3 N 4 nanocomposite: Application for picomolar-level electrochemical detection of endocrine disruptor (Bisphenol-A) in humans and animals

Bisphenol A (BPA) is an endocrine-disrupting chemical which resembles structurally the hormone estrogen. Even a trace amount of BPA can bind estrogen receptors resulting in the inducement of reproductive disorders, cancers and problems related to sexual growth such as manliness in female and womanli...

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Bibliographic Details
Published in:Ultrasonics sonochemistry 2019-11, Vol.58, p.104629
Main Authors: Ponnaiah, Sathish Kumar, Prakash, Periakaruppan, Muthupandian, Saravanan
Format: Article
Language:English
Subjects:
Aniline Compounds - chemistry
Animals
Benzhydryl Compounds - chemistry
Benzhydryl Compounds - urine
Chemistry Techniques, Synthetic
Electrochemistry - instrumentation
Electrochemistry - methods
Electrodes
Endocrine Disruptors - chemistry
Endocrine Disruptors - urine
Humans
Limit of Detection
Metal Nanoparticles - chemistry
Models, Molecular
Molecular Conformation
Nanocomposites - chemistry
Nanotechnology
Nitriles - chemistry
Phenols - chemistry
Phenols - urine
Ruthenium - chemistry
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Summary:Bisphenol A (BPA) is an endocrine-disrupting chemical which resembles structurally the hormone estrogen. Even a trace amount of BPA can bind estrogen receptors resulting in the inducement of reproductive disorders, cancers and problems related to sexual growth such as manliness in female and womanliness in male. So the determination of BPA in human and animal bodies is very essential. For this purpose, a new nanocomposite composed of ruthenium nanoparticles, polyaniline and graphitic carbon nitride (Ru /PANI/g-C N ) has been synthesized ultrasonically (40 ± 3 kHz, 200 W). A modification on glassy carbon electrode (GCE) with the nanocomposite detects BPA in human and animal urine samples with wide linear range (0.01-1.1 µM) and the limit of detection is pico molar-level. The synthesized nanocomposite was characterized by Ultraviolet-Visible and Fourier Transform-Infra Red spectroscopies, thermo gravimetric analysis, transmission electron microscopy, X-ray diffraction study, energy dispersive X-ray analysis, and elemental mapping analysis. This sensing system is selective, stable and reusable, by which the detection of BPA in various physiological fluids is very much possible.
ISSN:1873-2828