Visible-light-triggered direct keto-difluoroacetylation of styrenes with (fluorosulfonyl)difluoroacetate and dimethyl sulfoxide leads to α-difluoroacetylated ketones

Photoredox-catalyzed direct keto-difluoroacetylation of styrenes with (fluorosulfonyl)difluoroacetate and dimethyl sulfoxide as an oxidant is disclosed. A variety of α-difluoroacetylated ketones bearing functional groups with good yields are obtained using fac -Ir(ppy) 3 as a photocatalyst under vis...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-09, Vol.55 (73), p.198-1983
Main Authors: Luo, Xuewei, Fan, Zhengning, Zhang, Bo, Chen, Chao, Xi, Chanjuan
Format: Article
Language:English
Subjects:
Dimethyl sulfoxide
Functional groups
Ketones
Light irradiation
NMR
Nuclear magnetic resonance
Styrenes
Sulfoxides
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Summary:Photoredox-catalyzed direct keto-difluoroacetylation of styrenes with (fluorosulfonyl)difluoroacetate and dimethyl sulfoxide as an oxidant is disclosed. A variety of α-difluoroacetylated ketones bearing functional groups with good yields are obtained using fac -Ir(ppy) 3 as a photocatalyst under visible light irradiation. Photoredox-catalyzed direct keto-difluoroacetylation of styrenes with methyl (fluorosulfonyl)difluoroacetate and dimethyl sulfoxide to deliver various α-difluoroacetylated ketones are disclosed.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc06037e