Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation

Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, topodiscs, are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, top...

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Bibliographic Details
Published in:Nanoscale 2019-09, Vol.11 (35), p.16214-16221
Main Authors: Bjrge, Isabel M, Choi, Insung S, Correia, Clara R, Mano, Joo F
Format: Article
Language:English
Subjects:
Animals
Biomedical materials
Cell Culture Techniques
Cell Differentiation
Cell Line
Differentiation (biology)
Mice
Osteogenesis
Substrates
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Summary:Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, topodiscs, are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors. Novel disc-like microparticles, herein termed as topodiscs, with grooved surface nanotopography effectively enhanced cell culture and allowed for a bottom-up engineering of 3D mineralized microtissues.
ISSN:2040-3364
2040-3372
DOI:10.1039/c9nr06267j