Effects of mono- and dialkylglucosides on the characterisation and blood circulation of lipid nanoemulsions

Aim: Effects of two cosurfactants, n-alkylglycosides with mono- or disaccharide groups - N-nonyl β-D-glucopyranoside (N-Glu) and N-decyl β-D-maltoside (D-Mal) - were studied to the stability in saline solution, interaction with serum albumin, and blood circulation of the lipid nanoemulsion (LNE). Me...

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Bibliographic Details
Published in:Journal of microencapsulation 2019-11, Vol.36 (8), p.738-746
Main Authors: Takegami, Shigehiko, Konishi, Atsuko, Okazaki, Shizuno, Fujiwara, Mai, Kitade, Tatsuya
Format: Article
Language:English
Subjects:
albumin interaction
Animals
blood circulation
Emulsions
Glucosides - chemistry
Lipid Droplets - chemistry
lipid nanoemulsion
Lipids - blood
Magnetic Resonance Spectroscopy
Male
Mice
n-Alkylglycoside
Nanoparticles
particle characterisation
Serum Albumin, Bovine - chemistry
Surface-Active Agents - chemistry
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Summary:Aim: Effects of two cosurfactants, n-alkylglycosides with mono- or disaccharide groups - N-nonyl β-D-glucopyranoside (N-Glu) and N-decyl β-D-maltoside (D-Mal) - were studied to the stability in saline solution, interaction with serum albumin, and blood circulation of the lipid nanoemulsion (LNE). Methods: The LNEs composed of soybean oil, phosphatidylcholine, and sodium palmitate were prepared without (Control-LNE) and with N-Glu or D-Mal (NG-LNE and DM-LNE, respectively). Results: In saline solution, NG-LNE exhibited a smaller droplet size than Control-LNE, while the size of DM-LNE was significantly increased compared with the other LNEs. The fluorescence resonance energy transfer method showed that the order of albumin interaction was DM-LNE > NG-LNE > Control-LNE. In vivo blood circulation in mice, showed greater fractions of both NG-LNE and DM-LNE remaining in blood over time compared with Control-LNE. Conclusions: The nature of high stability in saline solution and high affinity for serum albumin led to the prolonged circulation of LNE.
ISSN:0265-2048
1464-5246
DOI:10.1080/02652048.2019.1671909