Effects of mono- and dialkylglucosides on the characterisation and blood circulation of lipid nanoemulsions

Aim: Effects of two cosurfactants, n-alkylglycosides with mono- or disaccharide groups - N-nonyl β-D-glucopyranoside (N-Glu) and N-decyl β-D-maltoside (D-Mal) - were studied to the stability in saline solution, interaction with serum albumin, and blood circulation of the lipid nanoemulsion (LNE). Me...

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Published in:Journal of microencapsulation 2019-11, Vol.36 (8), p.738-746
Main Authors: Takegami, Shigehiko, Konishi, Atsuko, Okazaki, Shizuno, Fujiwara, Mai, Kitade, Tatsuya
Format: Article
Language:English
Subjects:
albumin interaction
Animals
blood circulation
Emulsions
Glucosides - chemistry
Lipid Droplets - chemistry
lipid nanoemulsion
Lipids - blood
Magnetic Resonance Spectroscopy
Male
Mice
n-Alkylglycoside
Nanoparticles
particle characterisation
Serum Albumin, Bovine - chemistry
Surface-Active Agents - chemistry
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cited_by cdi_FETCH-LOGICAL-c366t-f695a6054379ce7e06154b352b6f56d4df9065ffaa227021c3873eb25a816bc63
cites cdi_FETCH-LOGICAL-c366t-f695a6054379ce7e06154b352b6f56d4df9065ffaa227021c3873eb25a816bc63
container_end_page 746
container_issue 8
container_start_page 738
container_title Journal of microencapsulation
container_volume 36
creator Takegami, Shigehiko
Konishi, Atsuko
Okazaki, Shizuno
Fujiwara, Mai
Kitade, Tatsuya
description Aim: Effects of two cosurfactants, n-alkylglycosides with mono- or disaccharide groups - N-nonyl β-D-glucopyranoside (N-Glu) and N-decyl β-D-maltoside (D-Mal) - were studied to the stability in saline solution, interaction with serum albumin, and blood circulation of the lipid nanoemulsion (LNE). Methods: The LNEs composed of soybean oil, phosphatidylcholine, and sodium palmitate were prepared without (Control-LNE) and with N-Glu or D-Mal (NG-LNE and DM-LNE, respectively). Results: In saline solution, NG-LNE exhibited a smaller droplet size than Control-LNE, while the size of DM-LNE was significantly increased compared with the other LNEs. The fluorescence resonance energy transfer method showed that the order of albumin interaction was DM-LNE > NG-LNE > Control-LNE. In vivo blood circulation in mice, showed greater fractions of both NG-LNE and DM-LNE remaining in blood over time compared with Control-LNE. Conclusions: The nature of high stability in saline solution and high affinity for serum albumin led to the prolonged circulation of LNE.
doi_str_mv 10.1080/02652048.2019.1671909
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Methods: The LNEs composed of soybean oil, phosphatidylcholine, and sodium palmitate were prepared without (Control-LNE) and with N-Glu or D-Mal (NG-LNE and DM-LNE, respectively). Results: In saline solution, NG-LNE exhibited a smaller droplet size than Control-LNE, while the size of DM-LNE was significantly increased compared with the other LNEs. The fluorescence resonance energy transfer method showed that the order of albumin interaction was DM-LNE &gt; NG-LNE &gt; Control-LNE. In vivo blood circulation in mice, showed greater fractions of both NG-LNE and DM-LNE remaining in blood over time compared with Control-LNE. 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Methods: The LNEs composed of soybean oil, phosphatidylcholine, and sodium palmitate were prepared without (Control-LNE) and with N-Glu or D-Mal (NG-LNE and DM-LNE, respectively). Results: In saline solution, NG-LNE exhibited a smaller droplet size than Control-LNE, while the size of DM-LNE was significantly increased compared with the other LNEs. The fluorescence resonance energy transfer method showed that the order of albumin interaction was DM-LNE &gt; NG-LNE &gt; Control-LNE. In vivo blood circulation in mice, showed greater fractions of both NG-LNE and DM-LNE remaining in blood over time compared with Control-LNE. 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Methods: The LNEs composed of soybean oil, phosphatidylcholine, and sodium palmitate were prepared without (Control-LNE) and with N-Glu or D-Mal (NG-LNE and DM-LNE, respectively). Results: In saline solution, NG-LNE exhibited a smaller droplet size than Control-LNE, while the size of DM-LNE was significantly increased compared with the other LNEs. The fluorescence resonance energy transfer method showed that the order of albumin interaction was DM-LNE &gt; NG-LNE &gt; Control-LNE. In vivo blood circulation in mice, showed greater fractions of both NG-LNE and DM-LNE remaining in blood over time compared with Control-LNE. Conclusions: The nature of high stability in saline solution and high affinity for serum albumin led to the prolonged circulation of LNE.</abstract><cop>England</cop><pub>Taylor &amp; Francis</pub><pmid>31573357</pmid><doi>10.1080/02652048.2019.1671909</doi><tpages>9</tpages></addata></record>
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects albumin interaction
Animals
blood circulation
Emulsions
Glucosides - chemistry
Lipid Droplets - chemistry
lipid nanoemulsion
Lipids - blood
Magnetic Resonance Spectroscopy
Male
Mice
n-Alkylglycoside
Nanoparticles
particle characterisation
Serum Albumin, Bovine - chemistry
Surface-Active Agents - chemistry
title Effects of mono- and dialkylglucosides on the characterisation and blood circulation of lipid nanoemulsions
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