Loading…
Association between lifestyle, gender and risk for developing end-stage renal failure in IgA nephropathy: a case-control study within 10 years
Purpose: To investigate the potential association between lifestyles, including cigarette smoking, alcohol consumption, and physical exercise at the time of biopsy and the risk for developing end-stage renal failure (ESRF) among IgA nephropathy (IgAN) patients within 10 years. Methods: A case-contro...
Saved in:
| Published in: | Renal failure 2019-01, Vol.41 (1), p.914-920 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c562t-ca4f06f06d74351855fcf82dcff12f08163fae8dd3e955370be0aa14c2cbfb253 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c562t-ca4f06f06d74351855fcf82dcff12f08163fae8dd3e955370be0aa14c2cbfb253 |
| container_end_page | 920 |
| container_issue | 1 |
| container_start_page | 914 |
| container_title | Renal failure |
| container_volume | 41 |
| creator | Huang, Pei Pei Shu, Dan Hua Su, Zhen Luo, Sheng Nan Xu, Fei Fei Lin, Fan |
| description | Purpose: To investigate the potential association between lifestyles, including cigarette smoking, alcohol consumption, and physical exercise at the time of biopsy and the risk for developing end-stage renal failure (ESRF) among IgA nephropathy (IgAN) patients within 10 years.
Methods: A case-control study was carried out. Seventy-seven ESRF patients with the primary cause of IgAN were enrolled as cases. Seventy-seven IgAN patients who had not progressed to ESRF after being diagnosed for over 10 years served as controls. Smoking, alcohol consumption and physical exercise related data and baseline clinical features were collected from their medical records and confirmed by phone calls.
Results: The case group had higher proportions of males, smokers, drinkers, and physical inactivity individuals than the controls had. Alcohol drinking history (/1 year, OR 1.32, p |
| doi_str_mv | 10.1080/0886022X.2019.1635029 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_31580172</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_2e2c5af7090c4eb184b76691f1ec1a88</doaj_id><sourcerecordid>2351034541</sourcerecordid><originalsourceid>FETCH-LOGICAL-c562t-ca4f06f06d74351855fcf82dcff12f08163fae8dd3e955370be0aa14c2cbfb253</originalsourceid><addsrcrecordid>eNp9kt-KEzEUxgdR3HX1EZSAN144NclMZjJeiGXxT2HBGwXvwpnMSZuaJjWZ2dKn8BV8Fp_M1HYX1wshkJDzO19yPr6ieMrojFFJX1EpG8r51xmnrJuxphKUd_eKcya4KBtad_eL8wNTHqCz4lFKa0qZkC1_WJxV-UBZy8-LH_OUgrYw2uBJj-MO0RNnDaZx7_AlWaIfMBLwA4k2fSMmRDLgNbqwtX5JcrVMIyyRRPTgiAHrpojEerJYzonH7SqGLYyr_WsCREPCUgc_xuBIGqdhT3Z2XGWY0V8_9wgxPS4eGHAJn5z2i-LL-3efLz-WV58-LC7nV6UWDR9LDbWhTV5DW1eCSSGMNpIP2hjGDZXZDwMoh6HCToiqpT1SAFZrrnvTc1FdFIuj7hBgrbbRbiDuVQCr_lyEuFQQR6sdKo5cCzAt7aiusWey7tum6ZhhqBlImbXeHLW2U7_BQWMeENwd0bsVb1dqGa5V00pWiyYLvDgJxPB9ytarjU0anQOPYUqKV5SKrqtlm9Hn_6DrMMVs_YESjFa1qFmmxJHSMaQU0dx-hlF1iI-6iY86xEed4pP7nv09yW3XTV4y8PYIWJ-TsIFdiG5QI-xdiCaC1zZl-L9v_AZiCtgL</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2351034541</pqid></control><display><type>article</type><title>Association between lifestyle, gender and risk for developing end-stage renal failure in IgA nephropathy: a case-control study within 10 years</title><source>Taylor & Francis Open Access</source><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Huang, Pei Pei ; Shu, Dan Hua ; Su, Zhen ; Luo, Sheng Nan ; Xu, Fei Fei ; Lin, Fan</creator><creatorcontrib>Huang, Pei Pei ; Shu, Dan Hua ; Su, Zhen ; Luo, Sheng Nan ; Xu, Fei Fei ; Lin, Fan</creatorcontrib><description>Purpose: To investigate the potential association between lifestyles, including cigarette smoking, alcohol consumption, and physical exercise at the time of biopsy and the risk for developing end-stage renal failure (ESRF) among IgA nephropathy (IgAN) patients within 10 years.
Methods: A case-control study was carried out. Seventy-seven ESRF patients with the primary cause of IgAN were enrolled as cases. Seventy-seven IgAN patients who had not progressed to ESRF after being diagnosed for over 10 years served as controls. Smoking, alcohol consumption and physical exercise related data and baseline clinical features were collected from their medical records and confirmed by phone calls.
Results: The case group had higher proportions of males, smokers, drinkers, and physical inactivity individuals than the controls had. Alcohol drinking history (/1 year, OR 1.32, p < .05) is independently associated with an increased risk of ESRF, while physical exercise habits (OR 0.06, p < .05) associated with a decreased risk of ESRF in multivariate logistic analysis. Male gender, lower eGFR, and higher urinary protein at the time of biopsy were also independent risk factors. Moreover, male-non-exercise population seems to be more likely to progress to ESRF than others (male-exercise, female-exercise, and female-none-exercise populations).
Conclusion: Physical exercise should be encouraged in IgAN patients, especially in males, for a better renal outcome. Alcohol cessation might have a renal survival benefit in IgAN patients.</description><identifier>ISSN: 0886-022X</identifier><identifier>EISSN: 1525-6049</identifier><identifier>DOI: 10.1080/0886022X.2019.1635029</identifier><identifier>PMID: 31580172</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adult ; Alcohol ; Alcohol drinking ; Alcohol Drinking - adverse effects ; Alcohol Drinking - epidemiology ; Alcohol use ; Biopsy ; Cigarette smoking ; Clinical Study ; Disease Progression ; Drinking behavior ; End-stage renal disease ; Epidermal growth factor receptors ; Exercise ; Exercise - physiology ; Female ; Follow-Up Studies ; Gender ; Glomerular Filtration Rate ; Glomerulonephritis, IGA - complications ; Glomerulonephritis, IGA - pathology ; Humans ; IgA ; IgA nephropathy ; Immunoglobulin A ; Kidney diseases ; Kidney Failure, Chronic - epidemiology ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - pathology ; Life Style ; Male ; Medical records ; Middle Aged ; Patients ; Renal failure ; Retrospective Studies ; Risk Factors ; Sex differences ; Sex Factors ; smoking</subject><ispartof>Renal failure, 2019-01, Vol.41 (1), p.914-920</ispartof><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2019</rights><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2019 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-ca4f06f06d74351855fcf82dcff12f08163fae8dd3e955370be0aa14c2cbfb253</citedby><cites>FETCH-LOGICAL-c562t-ca4f06f06d74351855fcf82dcff12f08163fae8dd3e955370be0aa14c2cbfb253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781456/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2351034541?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27502,27924,27925,37012,37013,44590,53791,53793,59143,59144</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31580172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Pei Pei</creatorcontrib><creatorcontrib>Shu, Dan Hua</creatorcontrib><creatorcontrib>Su, Zhen</creatorcontrib><creatorcontrib>Luo, Sheng Nan</creatorcontrib><creatorcontrib>Xu, Fei Fei</creatorcontrib><creatorcontrib>Lin, Fan</creatorcontrib><title>Association between lifestyle, gender and risk for developing end-stage renal failure in IgA nephropathy: a case-control study within 10 years</title><title>Renal failure</title><addtitle>Ren Fail</addtitle><description>Purpose: To investigate the potential association between lifestyles, including cigarette smoking, alcohol consumption, and physical exercise at the time of biopsy and the risk for developing end-stage renal failure (ESRF) among IgA nephropathy (IgAN) patients within 10 years.
Methods: A case-control study was carried out. Seventy-seven ESRF patients with the primary cause of IgAN were enrolled as cases. Seventy-seven IgAN patients who had not progressed to ESRF after being diagnosed for over 10 years served as controls. Smoking, alcohol consumption and physical exercise related data and baseline clinical features were collected from their medical records and confirmed by phone calls.
Results: The case group had higher proportions of males, smokers, drinkers, and physical inactivity individuals than the controls had. Alcohol drinking history (/1 year, OR 1.32, p < .05) is independently associated with an increased risk of ESRF, while physical exercise habits (OR 0.06, p < .05) associated with a decreased risk of ESRF in multivariate logistic analysis. Male gender, lower eGFR, and higher urinary protein at the time of biopsy were also independent risk factors. Moreover, male-non-exercise population seems to be more likely to progress to ESRF than others (male-exercise, female-exercise, and female-none-exercise populations).
Conclusion: Physical exercise should be encouraged in IgAN patients, especially in males, for a better renal outcome. Alcohol cessation might have a renal survival benefit in IgAN patients.</description><subject>Adult</subject><subject>Alcohol</subject><subject>Alcohol drinking</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Alcohol use</subject><subject>Biopsy</subject><subject>Cigarette smoking</subject><subject>Clinical Study</subject><subject>Disease Progression</subject><subject>Drinking behavior</subject><subject>End-stage renal disease</subject><subject>Epidermal growth factor receptors</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gender</subject><subject>Glomerular Filtration Rate</subject><subject>Glomerulonephritis, IGA - complications</subject><subject>Glomerulonephritis, IGA - pathology</subject><subject>Humans</subject><subject>IgA</subject><subject>IgA nephropathy</subject><subject>Immunoglobulin A</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic - epidemiology</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Kidney Failure, Chronic - pathology</subject><subject>Life Style</subject><subject>Male</subject><subject>Medical records</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Renal failure</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sex differences</subject><subject>Sex Factors</subject><subject>smoking</subject><issn>0886-022X</issn><issn>1525-6049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kt-KEzEUxgdR3HX1EZSAN144NclMZjJeiGXxT2HBGwXvwpnMSZuaJjWZ2dKn8BV8Fp_M1HYX1wshkJDzO19yPr6ieMrojFFJX1EpG8r51xmnrJuxphKUd_eKcya4KBtad_eL8wNTHqCz4lFKa0qZkC1_WJxV-UBZy8-LH_OUgrYw2uBJj-MO0RNnDaZx7_AlWaIfMBLwA4k2fSMmRDLgNbqwtX5JcrVMIyyRRPTgiAHrpojEerJYzonH7SqGLYyr_WsCREPCUgc_xuBIGqdhT3Z2XGWY0V8_9wgxPS4eGHAJn5z2i-LL-3efLz-WV58-LC7nV6UWDR9LDbWhTV5DW1eCSSGMNpIP2hjGDZXZDwMoh6HCToiqpT1SAFZrrnvTc1FdFIuj7hBgrbbRbiDuVQCr_lyEuFQQR6sdKo5cCzAt7aiusWey7tum6ZhhqBlImbXeHLW2U7_BQWMeENwd0bsVb1dqGa5V00pWiyYLvDgJxPB9ytarjU0anQOPYUqKV5SKrqtlm9Hn_6DrMMVs_YESjFa1qFmmxJHSMaQU0dx-hlF1iI-6iY86xEed4pP7nv09yW3XTV4y8PYIWJ-TsIFdiG5QI-xdiCaC1zZl-L9v_AZiCtgL</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Huang, Pei Pei</creator><creator>Shu, Dan Hua</creator><creator>Su, Zhen</creator><creator>Luo, Sheng Nan</creator><creator>Xu, Fei Fei</creator><creator>Lin, Fan</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20190101</creationdate><title>Association between lifestyle, gender and risk for developing end-stage renal failure in IgA nephropathy: a case-control study within 10 years</title><author>Huang, Pei Pei ; Shu, Dan Hua ; Su, Zhen ; Luo, Sheng Nan ; Xu, Fei Fei ; Lin, Fan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-ca4f06f06d74351855fcf82dcff12f08163fae8dd3e955370be0aa14c2cbfb253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Alcohol</topic><topic>Alcohol drinking</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Alcohol use</topic><topic>Biopsy</topic><topic>Cigarette smoking</topic><topic>Clinical Study</topic><topic>Disease Progression</topic><topic>Drinking behavior</topic><topic>End-stage renal disease</topic><topic>Epidermal growth factor receptors</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gender</topic><topic>Glomerular Filtration Rate</topic><topic>Glomerulonephritis, IGA - complications</topic><topic>Glomerulonephritis, IGA - pathology</topic><topic>Humans</topic><topic>IgA</topic><topic>IgA nephropathy</topic><topic>Immunoglobulin A</topic><topic>Kidney diseases</topic><topic>Kidney Failure, Chronic - epidemiology</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Kidney Failure, Chronic - pathology</topic><topic>Life Style</topic><topic>Male</topic><topic>Medical records</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Renal failure</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sex differences</topic><topic>Sex Factors</topic><topic>smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Pei Pei</creatorcontrib><creatorcontrib>Shu, Dan Hua</creatorcontrib><creatorcontrib>Su, Zhen</creatorcontrib><creatorcontrib>Luo, Sheng Nan</creatorcontrib><creatorcontrib>Xu, Fei Fei</creatorcontrib><creatorcontrib>Lin, Fan</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Renal failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Pei Pei</au><au>Shu, Dan Hua</au><au>Su, Zhen</au><au>Luo, Sheng Nan</au><au>Xu, Fei Fei</au><au>Lin, Fan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between lifestyle, gender and risk for developing end-stage renal failure in IgA nephropathy: a case-control study within 10 years</atitle><jtitle>Renal failure</jtitle><addtitle>Ren Fail</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>41</volume><issue>1</issue><spage>914</spage><epage>920</epage><pages>914-920</pages><issn>0886-022X</issn><eissn>1525-6049</eissn><abstract>Purpose: To investigate the potential association between lifestyles, including cigarette smoking, alcohol consumption, and physical exercise at the time of biopsy and the risk for developing end-stage renal failure (ESRF) among IgA nephropathy (IgAN) patients within 10 years.
Methods: A case-control study was carried out. Seventy-seven ESRF patients with the primary cause of IgAN were enrolled as cases. Seventy-seven IgAN patients who had not progressed to ESRF after being diagnosed for over 10 years served as controls. Smoking, alcohol consumption and physical exercise related data and baseline clinical features were collected from their medical records and confirmed by phone calls.
Results: The case group had higher proportions of males, smokers, drinkers, and physical inactivity individuals than the controls had. Alcohol drinking history (/1 year, OR 1.32, p < .05) is independently associated with an increased risk of ESRF, while physical exercise habits (OR 0.06, p < .05) associated with a decreased risk of ESRF in multivariate logistic analysis. Male gender, lower eGFR, and higher urinary protein at the time of biopsy were also independent risk factors. Moreover, male-non-exercise population seems to be more likely to progress to ESRF than others (male-exercise, female-exercise, and female-none-exercise populations).
Conclusion: Physical exercise should be encouraged in IgAN patients, especially in males, for a better renal outcome. Alcohol cessation might have a renal survival benefit in IgAN patients.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>31580172</pmid><doi>10.1080/0886022X.2019.1635029</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0886-022X |
| ispartof | Renal failure, 2019-01, Vol.41 (1), p.914-920 |
| issn | 0886-022X 1525-6049 |
| language | eng |
| recordid | cdi_pubmed_primary_31580172 |
| source | Taylor & Francis Open Access; Publicly Available Content Database; PubMed Central |
| subjects | Adult Alcohol Alcohol drinking Alcohol Drinking - adverse effects Alcohol Drinking - epidemiology Alcohol use Biopsy Cigarette smoking Clinical Study Disease Progression Drinking behavior End-stage renal disease Epidermal growth factor receptors Exercise Exercise - physiology Female Follow-Up Studies Gender Glomerular Filtration Rate Glomerulonephritis, IGA - complications Glomerulonephritis, IGA - pathology Humans IgA IgA nephropathy Immunoglobulin A Kidney diseases Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - etiology Kidney Failure, Chronic - pathology Life Style Male Medical records Middle Aged Patients Renal failure Retrospective Studies Risk Factors Sex differences Sex Factors smoking |
| title | Association between lifestyle, gender and risk for developing end-stage renal failure in IgA nephropathy: a case-control study within 10 years |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T10%3A06%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20lifestyle,%20gender%20and%20risk%20for%20developing%20end-stage%20renal%20failure%20in%20IgA%20nephropathy:%20a%20case-control%20study%20within%2010%C2%A0years&rft.jtitle=Renal%20failure&rft.au=Huang,%20Pei%20Pei&rft.date=2019-01-01&rft.volume=41&rft.issue=1&rft.spage=914&rft.epage=920&rft.pages=914-920&rft.issn=0886-022X&rft.eissn=1525-6049&rft_id=info:doi/10.1080/0886022X.2019.1635029&rft_dat=%3Cproquest_pubme%3E2351034541%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c562t-ca4f06f06d74351855fcf82dcff12f08163fae8dd3e955370be0aa14c2cbfb253%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2351034541&rft_id=info:pmid/31580172&rfr_iscdi=true |