Is a Universal Influenza Virus Vaccine Possible?

Influenza viruses remain a severe burden to human health because of their contribution to overall morbidity and mortality. Current seasonal influenza virus vaccines do not provide sufficient protection to alleviate the annual impact of influenza and cannot confer protection against potentially pande...

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Bibliographic Details
Published in:Annual review of medicine 2020-01, Vol.71 (1), p.315-327
Main Authors: Nachbagauer, Raffael, Palese, Peter
Format: Article
Language:English
Subjects:
Adjuvants
Epitopes
hemagglutinin
Immune response
Immunogenicity
Influenza
influenza virus
M2e
Morbidity
neuraminidase
Pandemics
universal vaccine
Vaccines
Viruses
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Summary:Influenza viruses remain a severe burden to human health because of their contribution to overall morbidity and mortality. Current seasonal influenza virus vaccines do not provide sufficient protection to alleviate the annual impact of influenza and cannot confer protection against potentially pandemic influenza viruses. The lack of protection is due to rapid changes of the viral epitopes targeted by the vaccine and the often suboptimal immunogenicity of current immunization strategies. Major efforts to improve vaccination approaches are under way. The development of a universal influenza virus vaccine may be possible by combining the lessons learned from redirecting the immune response toward conserved viral epitopes, as well as the use of adjuvants and novel vaccination platforms.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev-med-120617-041310